活动期类风湿关节炎前白蛋白\超敏C反应蛋白的变化及临床意义(1)
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【摘要】 目的 观察活动期类风湿关节炎(rheumatoid arthritis,RA)患者的前白蛋白(Prealbumin,PA)和超敏C反应蛋白(high-sensitivity C-reactive protein.hs-CRP)的变化及临床意义。方法 检测40例活动期RA及30例缓解期RA患者PA、hs-CRP,另设正常对照组30例并检测上述指标。结果 与正常对照组相比:RA活动组与RA缓解组PA均明显降低,有显著统计学意义(P<0.05或P<0.01);RA活动组与RA缓解组hs-CRP均明显升高,有显著统计学意义(P<0.01)与RA缓解组相比,RA活动组hs-CRP明显高于RA缓解组,有显著统计学意义(P<0.05),而RA活动组PA低于RA缓解组,但无统计学意义(P>0.05)。结论 RA是一种自身免疫性疾病,呈慢性过程,发作与缓解交替,对人体损害大,致残率高。而对于RA早期的诊断,目前应用的1987年美国风湿病学会诊断标准很难满足早期或不典型RA的诊断,而PA作为一种负急性时相蛋白,结合hs-CRP对于RA早期的诊断和判断病情轻重及预后具有重要意义。
【关键词】 类风湿关节炎;前白蛋白;超敏C反应蛋白
Changes of PA&hs-CRP of RA in Active Phase and Clinical significance
KONG Mei,XING Chang-yong,WANG Ying.Department of Clinical Laboratory,the Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China
【Abstract】 Objective Observing changes of RA patients’ PA & hs-CRP,as well as Clinical significance.Methods We examined 40 patients with active RA and 30 patients were in remission of RA patients with PA,hs-CRP,and normal control group of 30 patients and detected the target.Results Compared with the control group:RA activity group and the RA in remission were significantly lower PA,there was significant(P<0.05 orP<0.01);RA activity group and the RA in remission were significantly higher hs-CRP,there was significant(P<0.01); compared with RA in remission,RA activity group hs-CRP was significantly higher than RA in remission,there was significant(P<0.05),RA activity group PA was lower than RA remission group,but no statistical significance(P>0.05).Conclusion RA is a chronic process,attack and remission alternating、great damage on the human body,an autoimmune disease with high morbidity.As for the early diagnosis of RA,the current application of American College of Rheumatology 1987 diagnostic criteria difficult to meet the early or atypical diagnosis of RA,the PA as a negative acute phase proteins,combined with hs-CRP for early RA diagnosis and assessment of the severity and prognosis of great significance.
【Key words】 RA;PA;hs-CRP
类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性进行性关节病变为主的自身免疫炎性疾病,其发病率在自身免疫性结缔组织病中居首位,约侵害世界人口的1%~2%左右[1] ......
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