倍他乐克治疗慢性充血性心力衰竭的疗效观察(1)
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【摘要】 目的 观察倍他乐克治疗慢性充血性心力衰竭(CHF)的临床疗效。方法 选择CHF患者66例,分为观察组和对照组各33例。两组患者均给予常规抗心力衰竭治疗,观察组在此基础上加服倍他乐克6.25 mg,3次/d。治疗6个月后复查。观察两组治疗前后的心功能、超声心动图心功能指标。结果 观察组心功能改善总有效率87.9%,对照组的总有效率66.7%,两组间比较差异有统计学意义(P<0.05)。观察组的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)与对照组相比差异有统计学意义(P<0.01)。结论 CHF患者服用倍他乐克可有效改善心功能,增加其运动量。
【关键词】 慢性充血性心力衰竭;倍他乐克;疗效
Metoprolol in the treatment of chronic congestive heartfailure
ZHONG Dong.Department of Cardiology,The First People’s hospital of Fangcheng City,Fangcheng,Guangxi,Fangcheng 538021,China
【Abstract】 Objective To observe the therapeutic effect of Metoprolol in treating patients with chronic congestive heart failure(CHF).Methods 66 patients with CHF were divided into observation group and control group(33 cases each group).All patients were received conventional anti-heart failure treatment,the patients of observation group used Metoprolol 6.25 mg tid on the basis of conventional treatment.The pretherapy and post-treatment heartfunction,change of echocardiography of two groups were compared.Results The total effective rate of improving heart function in observation group was 87.9%,it was 66.7%in control group,the difference between the two groups was statistically significant(P<0.05).The difference of left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF)of two groups were statistically significant(P<0.05).Conclusion Metoprolol can improve heart function and increase their physical activity in treating CHF patients.
【Key words】Chronic congestive heart failure;Metoprolol;Therapeutic effect
慢性充血性心力衰竭(chronic congestive heart failure,CHF)是各种心脏疾病的终末阶段,严重影响患者的生活质量,是大多数心血管疾病的最终归宿。患者的症状和体征不具有特异性,早期诊断,充分治疗可显著改善其预后。目前常规药物治疗心力衰竭患者死亡率仍较高[1],探讨药物干预作用机制,对提高心力衰竭患者的治疗效果有重要意义。
倍他乐克是一种独特的调节心肌能量代谢产生途径的药物,是一种新型的抗心肌缺血药物,在稳定型心绞痛的治疗中取得了良好的疗效。近年来逐渐用于CHF的治疗。已有研究证实倍他乐克能提高CHF患者的左室射血分数(LVEF),改善症状。本研究旨在探讨倍他乐克治疗CHF的临床疗效。
1 资料与方法
1.1 一般资料 选择2005年7月至2008年7月在本院心内科住院且随访达6 个月的CHF患者66例,均符合中华医学会心血管病分会推荐的心力衰竭的临床评定标准[2]。其中男39例,女27例,NYHA 心功能分级Ⅱ~Ⅳ级,窦性心律,左室射血分数(LVEF)<40% ......
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