【摘要】 瑞芬太尼因其起效迅速和消除不依赖输注时间而广泛用于静脉麻醉,但其所诱发的痛觉过敏现象却越来越受到重视。对瑞芬太尼诱发痛觉过敏的机制及其预防措施进行研究,不仅为临床正确用药提供指导,还有助于新药的研发。

    【关键词】 瑞芬太尼;痛觉过敏;机制;预防

    Advance in studies of hyperalgesia induced by remifentanil

    WANG Zhe-yin,YANG Ya-li,REN Yong-gong.Department of Anesthesiology,Second Affiliated Hospital of Medical College,Jinan University,Shenzhen 518020,China

    【Abstract】 Remifentanil has gained increasing popularity as an opioid for intravenous anaesthesia due to its fast and predictable onset and offset independenting of the infusion time.However,more and more attention has been paid to the hyperalgesia induced by remifentanil.Research of the mechanisms and preventions of hyperalgesia induced by remifentanil not onlyprovides clinical guidement of medicine usage,but also contributes to the development of new drug.

    【Key words】Remifentanil; Hyperalgesia; Mechanism; Prevention

    阿片药物所诱发的痛觉过敏OIH(opioid-induced hyperalgesia)是指暴露于阿片药物的患者出现一种以痛阈降低和(或)对正常疼痛刺激的过激反应为特点的皮肤感觉异常现象 ......