氟尿嘧啶缓释剂联合适形放疗治疗老年食管癌的临床观察(1)
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【摘要】 目的 观察三维适形放疗联合氟尿嘧啶缓释剂治疗老年食管癌的临床疗效和毒副反应。方法 89例老年食管癌患者随机分为两组:观察组45例植入氟尿嘧啶缓释剂后开始放疗;对照组44例行单纯适形放疗。治疗完成后评价疗效和不良反应。结果 治疗组近期总有效率93.3%,1、2年生存率分别为84.4%、68.9%;对照组总有效率79.5%,1、2年生存率分别为63.6%、38.6%,两组间差异有统计学意义(P<0.05)。1、2年局部控制率治疗组为 88.9%、80.0%,对照组为70.5%、59.1%,两组间差异有统计学意义(P<0.05)。治疗过程中出现的不良反应较轻,患者均能耐受,两组间无统计学差异。结论 氟尿嘧啶联合三维适形放疗治疗老年食管癌安全、有效,值得临床进一步研究。
【关键词】 食管肿瘤;氟尿嘧啶植入剂;三维适形放疗
Clinical Observation On Fluorouracil Implants And Concurrent Radiotherapy In Elderly Esophageal Cancer
LI Ying,LIU Jian-min,WANG Cheng-hong,et al.Department of Radiation Oncology,LiaoCheng City the Second Hospital,Liao Cheng 252600,China
【Abstract】 Objective To observe the clinical effect and toxicity of three dimension conformal radiotherapy (3D-CRT) combined with slow-released fluorouracil in elderly esophageal cancer.Methods Eighty-nine elderly esophageal cancer patients were divided two groups:35cases of the treatment group were given 3D-CRT after slow-released fluorouracil was implanted,44 cases of control group received 3D-CRT alone.The clinical effect and toxicity was assessed after treatment.Results The recent total effective rate of the treatment group was 93.3%,the1 and 2 year survival rate of the treatment group was 84.4%and 68.9%respectively; The recent total effective rate of the control group was 79.5%,the 1and 2-year survival rate of the control group was 63.6%and 38.6%respectively.There was statistical significant difference between the two groups (P>0.05).The local control rate of 1 and 2-year in treatment groups was 88.9%and 80.0%respectively; the local control rate of 1 and 2-year in control groups was 70.5%and 59.1%respectively; There was statistical significance difference between the two groups.During the treatment,the patients had light toxical effect and could impatient.Conclusion Three dimension conformal radiotherapy (3DCRT) combined with slow-released fluorouracil in elderly esophageal cancer issafty、effective and valuable clincial study.
【Key words】Esophageal carcinoma; Fluorouracil Implants; 3D-CRT
2004年3月至2008年5月确诊为食管癌的老年患者89例,随机分成两组,观察组45例,进行内镜下氟尿嘧啶缓释剂植入加适形放疗,并与对照组44例仅行单纯适形放疗进行对比研究,现将结果报告如下。
1 资料与方法
1.1 入组条件 所有病例均为初治患者,年龄大于70岁,均经过钡餐、内镜和食管活检证实为隆起型食管鳞癌,无手术条件或手术难以切除的以及不愿手术的,均经胸部CT、脏器B超检查未发现区域淋巴结转移及远地转移,生命体征平稳,肝、肾功、血象及出凝血机制正常,Karnofsky评分大于70分,无严重内科疾患,取得患者知情同意书 ......
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