蒙古族原发性高血压患者血尿酸水平与早期肾损害的关系(1)
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【摘要】 目的 探讨蒙古族原发性高血压患者血尿酸水平与早期肾损害的关系和可能机制。方法 选择蒙古族高血压患者86例,汉族高血压患者89例,分别采用尿素酶法测定血尿酸(UA)免疫比浊法测定胱抑素C(Cys-C)、β2微球蛋白(β2 m),进行比较分析。结果 蒙古族高血压组UA(456.32±45.49)μmol/L显著高于汉族高血压组(456.32±45.49)比UA(385.30±37.85)μmol/L(P<0.05)。蒙古族组及汉族组UA与Cys-C、β2 m均呈正相关(r=0.714、0.694;r=0.624、0.526;P<0.05),在Ccr<50 m1/min时,Ccr与UA(r=0.72)、Cys-C(r=0.68)、β2 m(r=0.75),SCr(r=0.65)均有较好相关性呈正相关,r分别为0.72、0.68、0.75、0.65。Ccr为50~80 ml/min时,Ccr与UA、Cys-C、β2 m的相关性,r分别为0.75、0.73、0.70,而Ccr与SCr的r值为0.55。结论 蒙古族高血压人群高尿酸血症患者更容易出现肾损害。
【关键词】 蒙古族;高血压;血尿酸;肾损害
Relationship between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension
HE Wen-shuai,ZHAO Xing-sheng,WEN Xia,et al.Department of Cardiovasology,Inner Mongolia Hospital,Huhhot 010017,China
【Abstract】 Objective To discuss the relationship and possible mechanism between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension.Methods The patients with high blood pressure were chosen as the subjets,which the Mongolian patients were 86 cases and Han 89 cases.They were separately detected UA in the method of urease and Cys-C,β2 m in the way of turbidimetric immunoassay.The data concerned were compared with each other.Results In Mongolian patients group with high-blood pressure,the rate of uric acid was (456.32±45.49)μmol/L; that of Hanpatients group was (385.30±37.85)μmol/L.The rate of uric acid between Mongolian group and Han group showed apparent difference(P<0.05).UA showed positive correlation with Cys-c(r=0.714、0.694,P<0.05)while UA showed positive correlation with β2 m(r=0.624、0.526,P<0.05)in the Mongolian group and in the Han group.CCr showed correlation with UA、Cys-c、β2 m when CCr<50 ml/min,r was 0.72、0.68、0.75、0.65 respectively; CCr showed correlation with UA、Cys-c、β2 m when CCr was 50-80 ml/min,r was 0.75,0.73,0.70.CCr showed correalation with SCr,r was 0.55.Conclusion Those Mongolian patients with hypertension were more likely to show the symptoms of renal injury and metabolic disorder ......
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