鼻咽部弥漫性大B细胞淋巴瘤临床病理分析
【摘要】 目的 探讨鼻咽部弥漫性大B细胞淋巴瘤(DLBCL)的临床病理特征以提高诊断水平。方法 回顾性分析12例鼻咽部DLBCL患者临床病理资料，所有病例均进行CD20、CD3、CD10 、BCL6、MUM-1、Ki-67免疫表型测定，部分加做AE1/3、CD30、ALK、CD5和CyclinD1。结果 12例鼻咽部DLBCL均为原发，男8例，女4例，年龄34～67岁，平均48岁；5例临床误诊为鼻咽癌。生发中心细胞型7例，活化的B细胞型5例。结论 鼻咽部DLBCL极易误诊为鼻咽癌，形态学、免疫表型及临床表现三者结合可确诊。【关键词】 淋巴瘤；弥漫性；鼻咽部；病理学；鉴别诊断
Analysis on the clinicopathology characteristics of diffuse large B-cell lymphoma in asopharyngeal
ZHENG Cheng-cai, WANG Wei-guang,WANG Gang-pin.
Department of ENT,Affiliated Donggang Hospital of Shandong University, Rizhao 276826, China
【Abstract】 Objective To investigate the clinicopathology characteristics of asopharyngeal diffuse large B-cell lymphoma(DLBCL)and improve diagnosis of the disease.Methods The clinical, immunophenotypic and histopathologic features of 12 cases asopharyngeal DLBCL were retrospectively studied. The expression of CD20,CD3,CD10,BCL6,MUM-1, Ki-67,CD30,AE1/3,CD30,ALK,CD5and CyclinD1 was detected. Results All patients were primary DLBCL. Among the 12 patients,8 were males and 4 were femals.The age ranged from 34 to 67 years,average age 48 years old. Among them,7 cases were germinal centre B-cell-like(GCB), 5 cases were non-germinal centre B-cell-like(non-GCB). Conclusion Asopharyngeal DLBCLs are easily misdiagnosed as carcinomas.The correct diagnosis of DLBCL may be reached by combination of clinic, histological and immunological features. ......
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