血浆FB\BNP\TNI\CRP浓度与急性冠脉综合征的关系(1)
[摘要] 目的 探讨血浆纤维蛋白原(FB)、钠尿肽(BNP)、肌钙蛋白I(TNI)、C反应蛋白(CRP)浓度与急性冠脉综合征(ACS)之间的关系。方法 将120例ACS患者作为研究组,39例稳定型心绞痛(SA)和41例健康者作为对照组,根据冠状动脉病变严重程度及是否发生心血管事件分组比较FB、BNP、TNI、CRP浓度变化。结果 治疗组FB、BNP、TNI、CRP浓度高于对照组(P<0.05);三支病变组高于双支、单支病变组(P<0.05),双支病变组高于单支病变组(P<0.05);Gensini评分≥20分组高于Gensini评分<20分组(P<0.05);发生心血管事件组高于未发生组(P<0.05)。结论 联合检测血浆FB、BNP、TNI及CRP浓度有助于ACS的诊断及预后评估。
[关键词] 急性冠脉综合征; 纤维蛋白原;钠尿肽;Gensini评分;心血管事件
[中图分类号] R543.31 [文献标识码] A [文章编号] 1673-9701(2009)36-10-03
, http://www.100md.com
Significance of Combined Detection of Fibrinogen,B-type Natriuretic Peptide,Troponin I and C-reactive Protein in Acute CoronarySyndrome
ZHU Peng1REN Hui2WAN Zhaofei2
1.Ankang City Central Hospital,Ankang 725007 China; 2. Department of Cardiology,the First Affiliated Hospital of Yan'an University,Yan'an 716000,China
[Abstract] Objective To study the relationship between the levels of plasma fibrinogen(FB), B-type natriuretic peptide(BNP), troponin I (TNI) and C-reactive protein(CRP) and acute coronary syndrome. Methods We chose 120 patients with acute coronary syndrome as research group and 39 patients with stable angina and 41 normal healthy subjects as control group. We grouped according to the severity of coronary artery lesion and the occurrence of cardiovascular events and compared plasma FB,BNP,TNI and CRP levels of different groups. Results The plasma FB, BNP, TNI and CRP levels in the research group were higher than those in the control group(P<0.05). In terms of plasma FB, BNP, TNI and CRP levels, he three-vessel disease group was higher than the double- and single-vessel disease groups(P<0.05),and the double-vessel disease group was higher than the single-vessel disease group(P<0.05),the Gensini score ≥ 20 group was higher than the Gensini score <20 group(P<0.05) and the group where cardiovascular events occurred was higher than the group where cardiovascular events didn’t occur(P<0.05). Conclusion The combined detection of plasma FB,BNP,TNI and CRP levels contributes to the diagnosis of acute coronary syndrome and prognosis evaluation.
, 百拇医药
[Key words] Acute coronary syndrome;Fibrinogen;Natriuretic peptide;Gensini score;Cardiovascular events
急性冠脉综合征(ACS)是指在冠状动脉粥样硬化的基础上发生的易损斑块破溃、表面糜烂或溃疡[1],血小板激活引起不完全或完全性急性阻塞性血栓病变,导致临床上常见的不稳定型心绞痛(UA)、非ST段抬高型心肌梗死(NSTEMI)及ST段抬高型心肌梗死(STEMI)。它起病急、危害大,一直是威胁人类生命的最主要疾病之一。因此及早准确诊断ACS,提前干预,对ACS的预后具有重要的临床意义。现在的研究分别提示血浆FB、BNP、TNI、CRP浓度为ACS的危险因素[2]。本文通过联合测定血浆FB、BNP、TNI、CRP浓度,评价其在ACS的诊断和预后评估中的价值。
1对象与方法
1.1一般资料
, http://www.100md.com
严格参照2006年中国《慢性稳定型心绞痛诊断治疗指南》,2007年中国《不稳定型心绞痛(UA)和非ST段抬高型心肌梗死(NSTEMI)的诊断和治疗指南》及全球心肌梗死工作组2006年对心肌梗死的新定义标准,选取2007年1月~2008年4月在我院心血管内科住院的初发急性冠脉综合征(ACS)患者120例作为研究组,其中男性63例,女性57例。年龄41~80岁,平均年龄(68.2±10.2)岁,其中ST段抬高型心肌梗死(STEMI)患者40例,非ST段抬高型心肌梗死(NSTEMI)患者38例和不稳定型心绞痛(UA)患者42例。并选取与之年龄、性别相匹配的39例稳定型心绞痛(SA)患者,41例健康者作为对照组。全部研究对象均经过选择性冠状动脉造影(CAG)来确诊或排除冠心病,冠状动脉狭窄与否与狭窄严重程度通过目测法和Gensini评分[3]来判定。
1.2仪器与试剂
血浆FB测定采用德国DADE BEHRING公司生产的凝血酶试剂,测定方法为凝血酶凝固法;血浆TNI、BNP测定采用美国博适公司的Triage诊断仪,测定方法采用免疫荧光法;血浆CRP测定采用浙江伊利康生物技术有限公司提供的CRP检测试剂盒,测定方法为免疫比浊法。选择性冠状动脉造影(CAG)检查采用美国GE公司生产的数字减影机,按标准Judkins法行CAG检查,三条心外膜下冠状动脉及其大分支任何一支直径出现≥50%的狭窄即可诊断为冠心病。, 百拇医药(祝 鹏 任 辉 万招飞)
[关键词] 急性冠脉综合征; 纤维蛋白原;钠尿肽;Gensini评分;心血管事件
[中图分类号] R543.31 [文献标识码] A [文章编号] 1673-9701(2009)36-10-03
, http://www.100md.com
Significance of Combined Detection of Fibrinogen,B-type Natriuretic Peptide,Troponin I and C-reactive Protein in Acute CoronarySyndrome
ZHU Peng1REN Hui2WAN Zhaofei2
1.Ankang City Central Hospital,Ankang 725007 China; 2. Department of Cardiology,the First Affiliated Hospital of Yan'an University,Yan'an 716000,China
[Abstract] Objective To study the relationship between the levels of plasma fibrinogen(FB), B-type natriuretic peptide(BNP), troponin I (TNI) and C-reactive protein(CRP) and acute coronary syndrome. Methods We chose 120 patients with acute coronary syndrome as research group and 39 patients with stable angina and 41 normal healthy subjects as control group. We grouped according to the severity of coronary artery lesion and the occurrence of cardiovascular events and compared plasma FB,BNP,TNI and CRP levels of different groups. Results The plasma FB, BNP, TNI and CRP levels in the research group were higher than those in the control group(P<0.05). In terms of plasma FB, BNP, TNI and CRP levels, he three-vessel disease group was higher than the double- and single-vessel disease groups(P<0.05),and the double-vessel disease group was higher than the single-vessel disease group(P<0.05),the Gensini score ≥ 20 group was higher than the Gensini score <20 group(P<0.05) and the group where cardiovascular events occurred was higher than the group where cardiovascular events didn’t occur(P<0.05). Conclusion The combined detection of plasma FB,BNP,TNI and CRP levels contributes to the diagnosis of acute coronary syndrome and prognosis evaluation.
, 百拇医药
[Key words] Acute coronary syndrome;Fibrinogen;Natriuretic peptide;Gensini score;Cardiovascular events
急性冠脉综合征(ACS)是指在冠状动脉粥样硬化的基础上发生的易损斑块破溃、表面糜烂或溃疡[1],血小板激活引起不完全或完全性急性阻塞性血栓病变,导致临床上常见的不稳定型心绞痛(UA)、非ST段抬高型心肌梗死(NSTEMI)及ST段抬高型心肌梗死(STEMI)。它起病急、危害大,一直是威胁人类生命的最主要疾病之一。因此及早准确诊断ACS,提前干预,对ACS的预后具有重要的临床意义。现在的研究分别提示血浆FB、BNP、TNI、CRP浓度为ACS的危险因素[2]。本文通过联合测定血浆FB、BNP、TNI、CRP浓度,评价其在ACS的诊断和预后评估中的价值。
1对象与方法
1.1一般资料
, http://www.100md.com
严格参照2006年中国《慢性稳定型心绞痛诊断治疗指南》,2007年中国《不稳定型心绞痛(UA)和非ST段抬高型心肌梗死(NSTEMI)的诊断和治疗指南》及全球心肌梗死工作组2006年对心肌梗死的新定义标准,选取2007年1月~2008年4月在我院心血管内科住院的初发急性冠脉综合征(ACS)患者120例作为研究组,其中男性63例,女性57例。年龄41~80岁,平均年龄(68.2±10.2)岁,其中ST段抬高型心肌梗死(STEMI)患者40例,非ST段抬高型心肌梗死(NSTEMI)患者38例和不稳定型心绞痛(UA)患者42例。并选取与之年龄、性别相匹配的39例稳定型心绞痛(SA)患者,41例健康者作为对照组。全部研究对象均经过选择性冠状动脉造影(CAG)来确诊或排除冠心病,冠状动脉狭窄与否与狭窄严重程度通过目测法和Gensini评分[3]来判定。
1.2仪器与试剂
血浆FB测定采用德国DADE BEHRING公司生产的凝血酶试剂,测定方法为凝血酶凝固法;血浆TNI、BNP测定采用美国博适公司的Triage诊断仪,测定方法采用免疫荧光法;血浆CRP测定采用浙江伊利康生物技术有限公司提供的CRP检测试剂盒,测定方法为免疫比浊法。选择性冠状动脉造影(CAG)检查采用美国GE公司生产的数字减影机,按标准Judkins法行CAG检查,三条心外膜下冠状动脉及其大分支任何一支直径出现≥50%的狭窄即可诊断为冠心病。, 百拇医药(祝 鹏 任 辉 万招飞)