术前放疗对子宫颈癌患者血清VEGF\SCC-Ag的影响(1)
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[摘要]目的 探讨子宫颈癌患者手术治疗前放疗对血清血管内皮生长因子(VEGF)、鳞状细胞癌抗原(SCC-Ag)水平的影响。方法 选择我院肿瘤科子宫颈癌患者65例，随机分为观察组(33例)和对照组(32例)，对照组行单纯手术治疗，观察组在手术前进行放疗，对比分析两组患者治疗前后的血清VEGF、SCC-Ag变化及近期预后情况。结果 观察组和对照组术后血清VEGF、SCC-Ag含量均较治疗前降低，差异有统计学意义(P<0.05或P<0.01)，且观察组优于对照组(P<0.05)；观察组近期生存率为90.91%，优于对照组的71.88%(P<0.05)，但两组之间并发症发生率差异无统计学意义(P>0.05)。 结论 术前放疗可明显降低子宫颈癌患者血清VEGF、SCC-Ag水平，且预后较好。
[关键词]子宫颈癌；放射治疗；手术；血管内皮生长因子；鳞状细胞癌抗原
[中图分类号] R734.2 [文献标识码]B [文章编号] 1673-9701(2011)25-73-02
Effects of Preoperative Radiotherapy for Serum VEGF，SCC-Ag in Patients with Carcinoma of Uterine Cervix
LU Anna
Oncology Department of Hangzhou Hospital Attached Armed Police in Zhejiang Province，Hangzhou，310051，China
[Abstract] Objective To explore the effects of preoperative radiotherapy for serum vascular endothelial growth factor(VEGF)，squamous cell carcinoma antigen(SCC-Ag) in patients with carcinoma of uterine cervix. Methods All 65 cases with carcinoma of uterine cervix in oncology department of our hospital were randomly divided into observation group(33 cases) and control group(32 cases). The control group treated only with operation.The observation group treated with preoperative radiotherapy.Comparative analysis the serum VEGF， SCC-Ag of two group patients before and after treatment. Results The serum VEGF， SCC-Ag of two groups after operation were decline than pretherapy，and was statistically significant difference(P<0.05 or P<0.01).The observation group was better than control group(P<0.05).The recent survival rate in observation group was 90.91% which was better than 71.88% in control group(P<0.05). There was no significant difference for complication in these two groups(P>0.05).Conclusion Preoperative radiotherapy can clear reduce the level of serum VEGF，SCC-Ag in patients with carcinoma of uterine cervix，and the prognosis is well.
[Key words] Carcinoma of uterine cervix；Radiotherapy；Operation；Vascular endothelial growth factor；Squamous cell carcinoma antigen
子宫颈癌是发生在子宫阴道部及宫颈管的恶性肿瘤，仅次于乳腺癌而位居妇科恶性肿瘤的第二位。手术是早期宫颈癌的主要治疗手段，但对于体积较大的癌瘤其预后不尽理想。研究表明，血管内皮生长因子(VEGF)和鳞状细胞癌抗原(SCC-Ag)与子宫颈癌的进展密切相关[1-2]。本文通过研究早期子宫颈癌患者术前放射治疗对血清VEGF、SCC-Ag的影响 ......
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