重组人脑利钠肽治疗充血性心力衰竭的效果观察(1)
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[摘要] 目的 探讨重组人脑利钠肽治疗充血性心力衰竭的临床效果。方法 选取充血性心力衰竭患者86例，随机分为对照组和观察组，两组均给予常规治疗，观察组在此基础上给予重组人脑利钠肽，观察治疗效果。结果 两组LVD、LVWP及HR与治疗前比较均明显降低，LVEF明显升高，且观察组LVD、LVWP、LVEF、HR的改善幅度明显大于对照组(P<0.05)；治疗总有效率明显高于对照组，不良反应发生率明显低于对照组(P<0.05)。结论 重组人脑利钠肽治疗充血性心力衰竭具有较好的临床效果，且可以降低不良反应的发生率，安全性较高。
[关键词] 充血性心力衰竭；重组人脑利钠肽
[中图分类号] R541.6+1 [文献标识码] B [文章编号] 1673-9701(2011)26-62-02
Observation of Clinical Effect of Brain Natriuretic Peptide on Congestive Heart Failure
CHEN Guofan
Department of Cardiology，Hangzhou Teacher University Affiliated Hospital，Hangzhou 650031，China
[Abstract] Objective To explore clinical effect of recombinant human brain natriuretic peptide(rhBNP) on congestive heart failure. Methods All 86 cases with congestive heart failure in our hospital were selected and were randomly divided into observed group and control group. Two groups received routine treatment，patients in the observed group were treated with rhBNP on the based of routine treatment. We observed the effect of two groups. Results LVD，LVWP，HR all decreased and LVEF increased in two groups after treatment compared with before treatment and the change of LVD，LVWP，LVEF，HR in the observed group were significantly greater than those in the control group(P<0.05). The overall response rate was significantly higher and the adverse effect rate was significantly lower in the observed group than that in the control group(P<0.05). Conclusion Clinical effect of recombinant human brain natriuretic peptide on congestive heart failure is satisfied and can decrease the occurring rate of adverse reactions，it has the good safety and is well worth clinical popularizing and application.
[Key words] Congestive heart failure；Recombinant human brain natriuretic peptide(rhBNP)
充血性心力衰竭(CHF)是各种心脏疾患的终末阶段，是一种复杂的临床综合征，严重影响人们的生命安全[1]。其主要特征是神经内分泌激活和重构。临床上对其治疗多采用利尿剂、洋地黄药物、硝酸脂类等药物，但没有收到满意的治疗效果。重组人脑利钠肽(rhBNP)是一种通过重组DNA技术合成的多肽，临床上广泛应用于急性失代偿性心力衰竭患者的治疗，国内外已有较多的报道，而关于rhBNP治疗CHF患者的报道较少[2]。笔者选取2010年1～12月来我院就诊的充血性心力衰竭患者86例，分别采用常规治疗和给予重组人脑利钠肽治疗，以观察重组人脑利钠肽对充血性心力衰竭患者的治疗效果，现将结果总结报道如下。
1 资料与方法
1.1 一般资料
选取2010年1～12月来我院就诊的充血性心力衰竭患者86例，所有患者均经过X线片、心电图检查确诊。男51例，女35例，年龄37～81岁，平均(65.1±11.9)岁；心力衰竭病程4d～25年，平均(13.6±4.1)年；发病原因：冠心病29例，扩张型心肌病23例 ......
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