补充双歧三联活菌对大肠癌术后肠道菌群影响的研究(1)
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[摘要] 目的 探讨补充双歧三联活菌对大肠癌术后肠道菌群的影响。方法 将我院收治的大肠癌患者随机分为观察组和对照组，对照组术前肠道准备采用传统方法，观察组在此基础上给予双歧三联活菌。结果 与手术前比较，对照组手术后大肠杆菌明显增加，双歧杆菌及B/E明显降低，内毒素明显升高(P<0.05)。观察组手术后双歧杆菌及B/E明显降低(P<0.05)。两组治疗后B/E、阳性率、术后感染并发症均有显著性差异(P<0.05)。结论 术前补充双歧三联菌能够改善大肠癌患者的术前肠道菌群失调，有利于术后肠道菌群重建，使术后并发症明显降低。
[关键词] 大肠癌；肠道菌群；双歧三联活菌
[中图分类号]R735.3+4[文献标识码] B [文章编号] 1673-9701(2011)27-82-03
Influence of Supplement of Bifid Tiple Viable on Intestinal Flora of Patients with Colorectal Cancer after Operation
LI Guoqing
Emergency Department，NingboCity Zhenhai District People's Hospital,Ningbo 315202，China
[Abstract] Objective To explore the influence of supplement of bifid tiple viable on intestinal flora of patients with large intestinal cancer after operation. Methods Patients with large intestinal cancer were selected from our hospital and randomly divided into control group and observation group. Intestinal preparation preoperation of control group was received traditional methods observation group was given bifid tiple viable on the base of control group. Results Compared with preoperation, E.coli was higher, bifidobacterium and B/E were lower, endotoxin was higher in control group after operation(P<0.05). Bifidobacterium and B/E were significantly lower in observation group after operation(P<0.05). There were significant difference in B/E, the positive rate and the amplication between two groups after operation(P<0.05). Conclusion Supplement of bifid tiple viable on intestinal flora of patients with colorectal cancer before operation could improve colorectal cancer intestinal flora imbalance and reduce the amplication after operation.
[Key words] Colorectal cancer；Intestinal flora；Bifid Tiple Viable
大肠癌是临床最为常见的恶性肿瘤之一，在西方发达国家有较高的发病率。近年来，随着我国生活水平的提高，其发病率有上升趋势，成为影响我国人民健康的重要杀手之一[1]。临床上仍然主要采取根治性手术治疗，但其术后并发症严重影响患者恢复和预后，其中最常见并发症为术后肠道菌群失调。笔者选取近几年来我院就诊的大肠癌患者，分别采取术前肠道准备和在术前肠道准备的基础上补充双歧三联活菌方法，观察补充双歧三联活菌对大肠癌患者肠道菌群的影响，对术前肠道菌群失调、术后重建肠道菌群及并发症发生率的影响，现报道如下。
1资料与方法
1.1临床资料
选取2008年1月～2010年 1月我院收治的76例大肠癌患者，其中男40例，女36例，年龄40～79岁，平均年龄(65±10.7)岁，直肠癌37例，结肠癌39例。手术方法：行右半结肠切除术15例，左半结肠切除术16例，乙状结肠切除术11例，Dixon's术26例，Mile's术8例 ......
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