急性脑梗死患者血清同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的变化(1)
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[摘要] 目的 探讨急性脑梗死患者同型半胱氨酸、高敏C反应蛋白及D-二聚体水平的变化及临床意义。方法 2008年6月～2010年6月在我院收治的急性脑梗死患者110例，设立为梗死组，另选择同期我院健康体检者100例设为健康对照组，分别比较分析两组不同病灶及不同程度的Hcy、hs-CRP、DD的含量。其中Hcy、hs-CRP采用日本东芝TBA-40全自动生化分析仪检测。D-二聚体检测采用双抗体夹心法检测。结果 ①急性脑梗死组的110例患者血清中Hcy、hs-CRP、DD的含量均明显高于健康对照组，两组上述指标分别比较，差异有统计学意义(P<0.05或P<0.01)。②大梗死病灶患者的Hcy、hs-CRP、DD的含量明显高于中小梗死病灶的含量(P<0.05)。③重度梗死病灶患者的Hcy、hs-CRP、DD的含量明显高于轻度、中度梗死病灶的含量(P<0.05)。结论 急性脑梗死的发生、发展与Hcy、hs-CRP、D-二聚体关系密切，上述各指标将逐渐成为临床诊断急性脑梗死的常规检测指标，对脑梗死患者进行上述各指标的检测，能够为临床治疗提供可靠依据，从而起到重要的预防作用。
[关键词] 急性脑梗死；血清同型半胱氨酸；高敏C反应蛋白；D-二聚体水平
[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701(2011)32-77-02
Serum Homocysteine，High Sensitivity C-reactive Protein and D-dimer Levels in Acute Cerebral Infarction
DENG Bin DU Xiaopeng
Department of Neurology，Ningbo Minnesota Hospital in Zhejiang Province，Ningbo 315100，China
[Abstract] Objective To evaluate homocysteine in patients with acute cerebral infarction，high-sensitivity C-reactive protein and D-dimer levels and the clinical significance. Methods From June 2008 to June 2010 in our hospital 110 patients with acute cerebral infarction，established as infarction，another healthy choice in our hospital over the same period were 100 cases set to the healthy control group，respectively，a comparative analysis of two different lesions and different levels of Hcy，hs-CRP，DD levels. Which Hcy，hs-CRP with Japanese Toshiba TBA-40 automatic biochemical analyzer. D-dimer were detected by double-antibody sandwich assay. Results ① acute cerebral infarction，110 patients with serum Hcy，hs-CRP，DD levels were significantly higher than the control group，two sets of these indicators，respectively，the difference was statistically significant(P<0.05 or P<0.01). ②Large infarct lesion in patients with Hcy，hs-CRP，DD were significantly higher than the content of small infarction lesions，the difference was statistically significant. ③Lesions in patients with severe infarction Hcy，hs-CRP，DD were significantly higher than the mild ......
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