多潘立酮联合阿米替林治疗功能性消化不良的临床对照研究(1)
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[摘要] 目的 观察多潘立酮联合阿米替林治疗功能性消化不良(FD)临床效果及不良反应情况，探讨其临床价值及意义。方法 将120例FD患者随机分为观察组和对照组，对照组60例均给予单一多潘立酮口服治疗，观察组在此基础上加用阿米替林治疗，观察两组患者治疗21d后临床效果、症状改善情况及不良反应情况，并进行对比分析。结果 观察组有效率为96.67%(58/60)，对照组有效率为78.33%(47/60)，两组有效率比较有显著差异(P<0.05)；观察组治疗后症状积分明显低于对照组，组间比较有显著差异(P<0.05)；两组不良反应发生率比较无显著差异(P>0.05)。结论 多潘立酮联合阿米替林治疗FD具有疗效好、作用快、毒副作用少等优点，是目前治疗FD的一种较佳治疗方案，值得临床推广应用。
[关键词] 功能性消化不良；多潘立酮；阿米替林
[中图分类号] R975 [文献标识码] B [文章编号] 1673-9701(2011)35-60-02
The Clinical Control Study of Domperidone Combined Amitriptyline in Treatment of Functional Dyspepsia
CHEN Tao1 SHEN Lili2
1.Ten Ward of Rongjun Hospital in Zhejiang Province，Jiaxing 314000，China；2.The Senile Ward of Rongjun Hospital in Zhejiang Province，Jiaxing 314000，China
[Abstract] Objective To observe the clinical effect and side effects of combined amitriptyline and domperidone treatment to functional dyspepsia(FD) to study its clinical value and significance. Methods All of 120 patients with FD were randomly divided into the observation group and the control group，60 patients in the control group were given a single oral domperidone therapy，the control group were given the amitriptyline on the basis of the observation group，clin-ical results，improvement of symptoms and adverse reactions were observed and analyzed after 21d. Results The effective rate of the observation group was 96.67%(58/60)，and that of the control group was 78.33%(47/60)，which had significant differences among the two groups(P<0.05)；The symptom score of the observation group after treatment was significantly lower than that of the control group，whichwere significantly different(P<0.05)；The incidence of adverse reactions among the two groups had no significant difference(P>0.05). Conclusion For FD，domperidone combined with amitriptyline treatment is effective，fastacting，and less side effects，which is a better treatment for FD treatment，be worthy of clinical application.
[Key words] Functional dyspepsia；Domperidone；Amitriptyline
功能性消化不良(FD)是临床常见的一种胃肠动力障碍性疾病，是一种无器质性疾病的全身症候群，临床主要表现为持续性或反复发作性上腹不适、疼痛、胀气、早饱、反酸、烧心、恶心、呕吐等一系列症状，西药多潘立酮可有效改善胃动力、调节肠胃运动，但单一用药治疗效果欠佳[1]。近年来我科采用了多潘立酮联合阿米替林治疗方案治疗FD，临床上取得了满意效果，本文观察了60例经多潘立酮联合阿米替林治疗FD的临床疗效与不良反应情况，并与同期采用单一多潘立酮治疗FD的临床疗效进行了对比分析 ......
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