腺苷脱氨酶对肺炎支原体肺炎的辅助诊断作用(1)
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[摘要] 目的 探讨血清腺苷脱氨酶(ADA)检测在小儿肺炎支原体肺炎、普通肺炎诊断及鉴别诊断上的临床价值。 方法 对109例确诊肺炎支原体肺炎患儿、100例普通肺炎患儿(除外肺结核和肿瘤)以及100例正常健康儿童对照组的血清ADA进行回顾性统计分析。 结果 肺炎支原体肺炎组ADA值明显高于普通肺炎组ADA值和正常对照组ADA值， 差异具有高度统计学意义(P<0.01)， 普通肺炎组ADA值与正常对照组ADA值，差异无统计学意义(P>0.05)；支原体肺炎组中ADA(>25 U/L)的阳性率为33.03%，而普通肺炎组和正常对照组的的ADA值均<25 U/L，无阳性病例。 结论 ADA检测用于儿童支原体肺炎具有一定的诊断价值，在与普通肺炎的鉴别诊断上也有一定的临床应用价值。故有患儿血清ADA活性增高时，不能只考虑诊断为肺结核或恶性肿瘤等，而要考虑到肺炎支原体感染的可能性，对临床的诊断有一定的指导意义。
[关键词] 肺炎支原体肺炎；小儿；血清ADA活性；普通肺炎
[中图分类号] R725.6 [文献标识码] B [文章编号] 1673-9701(2012)01-088-02
Diagnostic value of serum adenosine deaminase activity in Mycoplasma penumonia
LI Huizhu LAN Xiucong LIU Wugao
Department of Pediatric，Zhejiang Province Lishui People's Hospital，Lishui 323000，China
[Abstract] Objective To explore the diagnostic value of serum adenosine deaminase activity in Mycoplasma penumonia and common penumonia. Methods Retrospective statistical analysis of ADA detected with autobiochemical analysis in 309 patients: 109 patients with Mycoplasma penumonia (in accordance with the diagnostic criteria of "Practical Pediatrics", mycoplasma antibody were positive), 100 cases of common pneumonia in children (except for tuberculosis and cancer) and 100 healthy children as controls. Results ADA of Mycoplasma pneumonia group was significantly higher than the ordinary pneumonia and normal control groups, the difference was significant (P<0.01); The difference of ADA values between ordinary pneumonia and the control group was no statistically significant (P>0.05); In Mycoplasma pneumonia group，the positive rate of ADA (>25 U/L) was 33.03%, while ADA values of the common pneumonia group and the normal control group were all <25 U/L. Conclusion The detection of ADA has a certain diagnosis value in children's Mycoplasma pneumonia, and has some clinical value in different diagnosis of common pneumonia. Therefore，when the serum ADA activity is increased, it can be not only considered the diagnosis of tuberculosis or m alignancy，but aslo take into account the possibility of Mycoplasma pneumoniae infection ......
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