生长抑素对急性胰腺炎胃肠动力的影响(1)
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[摘要] 目的 探讨生长抑素对急性胰腺炎胃肠动力的影响。 方法 选取我院80例急性胰腺炎患者，随机分为试验组和对照组，每组40例，两组均给予常规治疗，试验组给予生长抑素治疗，对照组给予5-氟尿嘧啶治疗。分析两组患者的治疗效果及胃肠动力变化。 结果 试验组总有效例数为38例，占95.0%；对照组总有效例数为37例，占92.5%，两组比较差异无统计学意义(χ2=0.21，P>0.05)；两组胃肠减压引流量比较，差异无统计学意义(t=1.77，P>0.05)；肠鸣音正常时间比较，差异有统计学意义(t=4.3，P<0.05)；肛门排气情况比较，差异有统计学意义(χ2=8.5，P<0.05)；血清淀粉酶恢复正常时间比较，差异有统计学意义(t=4.06，P<0.05)；肿瘤坏死因子恢复正常时间比较，差异有统计学意义(t=29.92，P<0.05)。 结论 生长抑素能保护胃肠黏膜和改善胃肠动力，对急性胰腺炎临床效果好。
[关键词] 急性胰腺炎；生长抑素；胃肠动力
[中图分类号] R576 [文献标识码] B [文章编号] 1673-9701(2012)02-0021-02
The effect of somatostatin on gastrointestinal motility in acute pancreatitis
CHEN Zhijun
Department of Medicine, the Third People's Hospital of Yuyao City in Zhejiang Province, Yuyao 315400, China
[Abstract] Objective To explore the influence of gastrointestinal dynamics with somatostatin to acute pancreatitis. Methods Choosed 80 patients with acute pancreatitis, randomly divided into trial group and control group, each group of 40 people. Two groups were given conventional treatments. The trail group were given somatostatin treatment, and the control group were given 5-fluorouracil treatment. Analysed 2 groups patients of the therapeutic effect and gastrointestinal changes. Results The total effective number of the patients was 38 cases, accounting for 95.0%; Control group total effective number was 37 cases, accounting for 92.5%, the comparisons of two groups (χ2=0.21, P>0.05); Gastrointestinal reduced pressure led flow rate (t=1.77, P>0.05); Normal bowelsound (t=4.3, P<0.05); The anus exhaust condition (χ2=8.5, P<0.05); Serum amylase resume normal (t=4.06, P<0.05); Tumor necrosis factor back to normal(t=29.92, P<0.05). Conclusion Somatostatin can protect the gastrointestinal mucous membrane and improve gastrointestinal dynamics, clinical effect was good.
[key words] Acute pancreatitis; Somatostatin; Gastrointestinal dynamics
急性胰腺炎是多种病因(主要是胆道梗阻和长期饮酒等)导致胰酶在胰腺内被激活后而导致胰酶对胰腺组织的自身消化从而引起胰腺水肿、出血甚至坏死等的一系列病理生理变化。临床表现主要是急性腹痛、腹胀、恶心、呕吐、发热和血胰酶增高等。急性胰腺炎患者早期就出现胃肠动力不足的表现[1]，包括胃潴留、肠麻痹等。目前除对急性胰腺炎采取常规治疗外，改善胃肠道动力功能的治疗也不容忽视，本文研究80例急性胰腺炎患者经不同的治疗方式治疗，旨在探求较好的改善胃肠道动力，并取得较好效果，现报道如下。
1 资料与方法 ......
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