早期血清pNF-H和S-100B的含量变化对颅脑损伤患者疗效的影响(1)
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[摘要] 目的 探讨颅脑损伤患者(早期)血清中神经丝蛋白H磷酸化亚型(pNF-H)和S-100B水平的变化对其疗效的影响。 方法 采用酶联免疫吸附法(ELISA)检测40名健康人和118例颅脑损伤患者损伤后6h、12h、24h、3d、5d、7d的血pNF-H和S-100B水平，分析pNF-H与格拉斯哥昏迷评分及预后的关系。 结果 观察组各时间点检测血pNF-H和S-100B浓度均显著高于对照组，差异有统计学意义(P均 < 0.05)；观察组内中、重型亚组各时间点检测血pNF-H浓度均显著高于轻型颅脑损伤亚组，差异有统计学意义(P均 < 0.05)；重型亚组各时间点血清pNF-H浓度均显著高于中型颅脑损伤亚组，差异有统计学意义(P均 < 0.05)；颅脑损伤后24h的血pNF-H水平与24h的GCS及6个月后格拉斯哥预后评分(GOS)呈负相关 (r = -0.47、-0.33, P均 < 0.05)。 结论 血pNF-H和S-100B水平检测可作为判断颅脑损伤早期病情和疗效的指标之一。
[关键词] 神经丝蛋白H磷酸化亚型；S-100B蛋白；颅脑损伤
[中图分类号] R651.1+5 [文献标识码] B [文章编号] 1673-9701(2012)04-0069-03
The early change and influencing factor of effect in treatment of serum pNF-H and S-100B in patients with traumatic brain injury
JIE Yuanqing
Department of Neuro Surgery, the People’s Hospital of Quzhou City in Zhejiang Province, Quzhou 324000, China
[Abstract] Objective To explore the early changes and curative effect of serum pNF-H and S-100B level in patients with traumatic brain injury. Methods Serum pNF-H and S-100B level of 40 healthy persons and 118 patients with traumatic brain injury were detected by ELISA method, and analysis the relationship with GCS and prognosis. Results The pNF-H and S-100B level of patients were higher than that of the control group(P < 0.05); the pNF-H level of medium and heavy group were higher than that of light group(P < 0.05); the pNF-H level of heavy group was higher than that of mediumgroup(P < 0.05); the pNF-H level of 24h after TBI has negative correlation with 24h GCS(P < 0.05) and 6month GOS(P < 0.05). Conclusion pNF-H and S-100B level examinations can be used for diagnosis of early brain injury and predict prognosis.
[Key words] pNF-H; S-100B; Traumatic brain injury
神经丝蛋白H磷酸化亚型(phosphorylated axonal form themajor neurofilament subunit NF-H，pNF-H)是神经丝蛋白H(neurofilament H，NF-H)的磷酸化亚型，被认为是可以反映轴突损伤的潜在标志物[1]。近期有研究表明，脑出血患者发病后检测血液中pNF-H和脑损伤标志物S-100B含量呈显著性变化[2]，但是关于颅脑损伤(TBI)患者早期血pNF-H水平变化对颅脑损伤预后的相关性研究较少，对颅脑损伤后和S-100B的含量变化已经有较多研究资料。本研究通过对颅脑损伤患者早期血pNF-H和脑损伤标志物S-100B蛋白浓度的测定，探讨pNF-H和S-100B对于颅脑损伤患者的预期疗效的意义。现报道如下。1 资料与方法
1.1一般资料
随机选择2010年10月～2011年4月单数日住院治疗的不同程度TBI患者118例为治疗组。病因为车祸伤、高处坠落伤、打伤等意外伤害。诊断为不同部位的脑挫裂伤 ......
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