二甲双胍联合谷胱甘肽治疗2型糖尿病合并非酒精性脂肪肝的疗效观察(1)
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[摘要] 目的 探讨二甲双胍联合谷胱甘肽治疗2型糖尿病合并非酒精性脂肪肝的临床效果。 方法 将我院2型糖尿病合并非酒精性脂肪肝患者60例随机分为观察组和对照组，观察组给予二甲双胍联合谷胱甘肽治疗，对照组给予维生素E治疗，评估两组治疗效果。 结果 治疗后观察组ALT、AST、TG、TC、HDL-C、LDL-C及BMI明显优于对照组，两者比较差异有统计学意义(P < 0.05)。观察组总有效率96.67%，对照组70.00%，两组比较差异有统计学意义(P < 0.05)。两组均未见明显的毒副作用。 结论 二甲双胍联合谷胱甘肽治疗2型糖尿病合并非酒精脂肪肝效果明显，值得应用。
[关键词] 二甲双胍；谷胱甘肽；非酒精性脂肪肝
[中图分类号] R575.5 [文献标识码] B [文章编号] 1673-9701(2012)04-0096-02
Observation on effect of diformin combined with glutathione in treatment of 2 type diabetes and nonalcoholic fatty liver
TANG Guowen ZENG Sheng LIN Shiyong CHEN Rujie
Department of Internal Medicine, the People's Hospital of Xuwen County, Guangdong Province, Xuwen 524100, China
[Abstract] Objective To investigate the effect of diformin combined with glutathione in treating cases with 2 type diabetes and nonalcoholic fatty liver. Methods The 60 cases with 2 type diabetes and nonalcoholic fatty liver were divided into the observe group and the control group. The observe group received the western medicine treatment, and the observe group received the treatment of conbined treatment of diformin conbined with glutathione, the control group received the treatment of vitamin E, and the effect was evaluated. Results The ALT, AST, TG, TC, HDL-C, LDL-C and BMI in the observe group after treatment were superior to those in control group, and there was significant difference in them (P < 0.05). The total effective rate was 96.67% in the observe group and 70.00% in the control group,and there was significant difference between them (P < 0.05). There was no significant side-effect in the two groups. Conclusion The effect of diformin conbined with glutathione in treating cases with 2 type diabetes and nonalcoholic fatty liver is obvious, so they are worth being used.
[Key words] Diformin; Glutathione; Nonalcoholic fatty liver
目前，随着人们饮食结构和生活方式的改变，2型糖尿病合并非酒精性脂肪肝(nonalcoholic fatty liver，NAFLD)的发病率越来越高，严重危害着人们的生活质量和生命安全，并普遍受到医学工作者的关注。该病目前尚无有效的治疗方法，我们采用二甲双胍联合谷胱甘肽治疗2型糖尿病合并非酒精性脂肪肝取得了满意的效果，现报道如下。
1 资料与方法
1.1 一般资料
选取2009年6月～2011年1月在我院住院治疗的2型糖尿病合并非酒精性脂肪肝患者60例 ......
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