[摘要] 目的 研究术前应用平阳霉素对喉癌诱导性化疗的临床疗效。 方法 选择2004年1月~2011年1月65例喉鳞状细胞癌患者为观察对象，术前所有对象用平阳霉素化疗。研究安全剂量范围内剂量与疗效的相关性，并采用免疫组化法检测术中活检的肿瘤、退缩区及正常组织。 结果 平阳霉素诱导性化疗对喉癌的总有效率为84.6%，疗效与给药剂量呈正相关，与肿瘤临床分期无明显相关。主要不良反应有发热、胃肠道反应、以及皮肤红斑等症状；化疗后肿瘤组织和退缩组织较之前明显凋亡。 结论 喉癌术前使用平阳霉素化疗副作用小，可缩小肿瘤，明确术中组织范围，安全剂量范围内使用可提高手术切除率，有助于抑制肿瘤细胞增殖，值得临床推广。

    [关键词] 喉癌；平阳霉素；诱导性化疗

    [中图分类号] R739.65[文献标识码] B[文章编号] 1673-9701(2012)10-0044-02

    Clinical study on the application of PYM induction chemotherapy before laryngocarcinoma operation

    WEN Qingquan LIAO Weiguo QI Qiguang TAN Guangmou

    Department of Head and Neck Surgery， Guangzhou Medical University Cancer Institute and Hospital，Guangzhou 510095，China

    [Abstract] Objective To study the clinical curative effect of the application of PYM induction chemotherapy before laryngocarcinoma operation. Methods All 65 patients with laryngeal squamous cell carcinoma from January 2004 to January 2011 were selected as observation objects, and received PYM chemotherapy before operation. The correlation between the dose in the safe range and the curative effect is studied, and also the IHC is used to test biopsy tumor, degenerating area and normal tissue. Results The total effective rate of PYM induction chemotherapy was 84.6%, and the curative effect was positively correlated with the dose and was not significantly correlated with the tumor clinical stages. The untoward effects include fever, gastrointestinal reaction, red skin spots, etc; the tumor and degenerating tissue were significantly apoptotic after chemotherapy. Conclusion The PYM induction chemotherapy before laryngocarcinoma operation has a side effect and can shrink the tumor; the application of PYM induction chemotherapy within the safe dose range can increase the resection rate, help inhibit tumor cells to proliferate, and hence can be promoted in the clinical field. ......