丙氨瑞林对子宫内膜癌裸鼠移植瘤的生长及FHIT表达的影响(2)
综上所述，GnRH及其类似物在一定程度上可以抑制子宫内膜癌的生长，其可能作为子宫内膜癌内分泌治疗的一种有效药物来应用，因此展示在肿瘤患者面前的将是一个广阔的前景。
[参考文献]
[1]Gallagher CJ，Oliver RT，Oram DH，et al. A new treatment for endometrial cancer with gonadotrophin releasing-hormone[J]. Br J Obstet Gynaecol，1991，98(10)：1037-1041.
[2]张玉泉，曹斌融，周先荣，等. 丙氨瑞林治疗子宫内膜癌后性激素及有丝分裂指数的变化[J]. 新药与临床，1996，15(4)：1942-1961.
[3]Grundker C，Gunthert AR，Westphalen S，et al. Biology of the gonadotrophin-releasing hormone system in gynecological cancers[J]. Eur J Endocrinol，2002，146(1)：1-14.
[4]Wang CB，Wang CJ，Huang HJ，et al. Fertility-preserving treatment in young patients with endometrial adenocarcinoma[J]. Cancer，2002，94(8)：2192-2198.
[5]Segawa T，Sasagawa T，Saijoh K，et al. Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas[J]. Clin Cancer Res，2000，6(6)：2341-2348.
[6]Ishii H，Dumon KR，Vecchione A，et al. Effect of adenoviral transduction of the fragile histidine trad gene into esophageal cancer cells[J]. Cancer Res，2001，61(4)：1578-1584.
[7]Su TH，Wang JC，Tseng HH，et al. Analysis of FHIT transcripts in cervical and endometrial cancers[J]. Int J Cancer，1998，76(2)：216-222.
[8]Ozaki K，Enomoto T，Yoshino K，et al. FHIT alterations in endometrial carcinoma and hyperplasia[J]. Int J Cancer，2000，85(3)：306-312.
(收稿日期：2012-02-02), http://www.100md.com(杜丽英 张三元)
[参考文献]
[1]Gallagher CJ，Oliver RT，Oram DH，et al. A new treatment for endometrial cancer with gonadotrophin releasing-hormone[J]. Br J Obstet Gynaecol，1991，98(10)：1037-1041.
[2]张玉泉，曹斌融，周先荣，等. 丙氨瑞林治疗子宫内膜癌后性激素及有丝分裂指数的变化[J]. 新药与临床，1996，15(4)：1942-1961.
[3]Grundker C，Gunthert AR，Westphalen S，et al. Biology of the gonadotrophin-releasing hormone system in gynecological cancers[J]. Eur J Endocrinol，2002，146(1)：1-14.
[4]Wang CB，Wang CJ，Huang HJ，et al. Fertility-preserving treatment in young patients with endometrial adenocarcinoma[J]. Cancer，2002，94(8)：2192-2198.
[5]Segawa T，Sasagawa T，Saijoh K，et al. Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas[J]. Clin Cancer Res，2000，6(6)：2341-2348.
[6]Ishii H，Dumon KR，Vecchione A，et al. Effect of adenoviral transduction of the fragile histidine trad gene into esophageal cancer cells[J]. Cancer Res，2001，61(4)：1578-1584.
[7]Su TH，Wang JC，Tseng HH，et al. Analysis of FHIT transcripts in cervical and endometrial cancers[J]. Int J Cancer，1998，76(2)：216-222.
[8]Ozaki K，Enomoto T，Yoshino K，et al. FHIT alterations in endometrial carcinoma and hyperplasia[J]. Int J Cancer，2000，85(3)：306-312.
(收稿日期：2012-02-02), http://www.100md.com(杜丽英 张三元)