心绞痛和脑梗死患者血浆TAT、D—D、ET水平变化及临床意义(1)
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[摘要] 目的 探讨心绞痛和脑梗死患者血浆TAT、D—D、ET水平变化及临床意义。 方法 检测心绞痛和脑梗死组各50例及对照组40例血浆TAT、D—D、ET。 结果 心绞痛组和脑梗死组血浆TAT、D—D、ET水平均显著高于对照组(P < 0.01)；不稳定型心绞痛TAT、D—D、ET水平均显著高于稳定型心绞痛(P < 0.05)；急性期脑梗死TAT水平显著高于亚急性、慢性期(P < 0.01)；亚急性期D—D水平显著高于急性期和慢性期(P < 0.05)。 结论 血浆TAT、D—D、ET水平反映了心绞痛和脑梗死患者凝血功能活跃、纤溶亢进、血管内皮损伤，有利于早期诊断和治疗。[关键词] 心绞痛；脑梗死；凝血；凝血酶—抗凝血酶复合物；D—二聚体；内皮素[中图分类号] R541.4；R743.33
[文献标识码] B
[文章编号] 1673—9701(2012)23—0031—02Plasma level changes and clinical significance of TAT， DD and ET in angina pectoris and cerebral infarctionCAI ShufengClinical Services Division， Central Blood Station of Wenzhou， Wenzhou
325001， China[Abstract] Objective To investigate the plasma levels changes and the clinical significance of TAT，DD and ET in angina pectoris and cerebral infarction. Methods The plasma TAT，DD and ET of angina and cerebral infarction group (n = 50) and control group (n = 40) were detected. Results The plasma level of TAT，DD and ET in angina pectoris and cerebral infarction group were significantly higher than that of control group (P < 0.01). The plasma level of TAT， DD and ET in unstable angina were significantly higher than that of stable angina (P < 0.05). The plasma level of TAT in acute cerebral infarction was significantly higher than the subacute and chronic phase (P < 0.01). The plasma level of DD in subacute phase group was significantly higher than the acute and chronic phases (P < 0.05). Conclusion Plasma levels of TAT，DD and ET reflect active angina and cerebral infarction in patients with clotting，fibrinolysis，vascular endothelial damage， early diagnosis and treatment.[Key words] Angina pectoris； Cerebral infarction； Coagulation； Thrombin—antithrombin complex； D—dimer； Endothelin血栓栓塞造成的心脑血管事件的发病率和病死率在不断地上升，严重危害人们的身体健康。了解其发生机制并早期诊断、预防是临床治疗的关键。本研究通过对检测心绞痛、脑梗死患者的止血和凝血分子标志，探讨其在血栓栓塞性心脑血管事件中所起的作用及意义，现报道如下 ......
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