丹红注射液对自然衰老大鼠心脏、大脑组织TNF—α、IL—6的影响(1)
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[摘要] 目的 探讨丹红注射液(DH)对自然衰老大鼠心脏、大脑组织肿瘤坏死因子—α(TNF—α)、白介素—6(IL—6)的影响。 方法 将40只雄性Wistar大鼠随机分为衰老组、Vit E组、丹红注射液大剂量组和丹红注射液小剂量组，每组10只。按照实验设计进行处理后，用ELISA法检测各组大鼠心脏、大脑组织中TNF—α、IL—6的水平。 结果 与衰老组相比，Vit E组、DH大剂量组和DH小剂量组大鼠心脏、大脑组织TNF—α、IL—6水平降低，差异有统计学意义(P < 0.05)；与DH小剂量组比较，DH大剂量组、Vit E组TNF—α、IL—6水平降低，差异有统计学意义(P < 0.05)。 结论 DH可下调大鼠心脏、大脑组织中TNF—α、IL—6水平，减轻机体的炎症反应，其可能参与了抗大鼠自然衰老的作用。
[关键词] 丹红注射液；衰老；肿瘤坏死因子—α；白介素—6
[中图分类号] R285.5 [文献标识码] A [文章编号] 1673—9701(2012)25—0001—01
Influences of danhong injection on TNF—α and IL—6 of heart and cerebrum in aged rats
LIU Lingzhi
Department of Cardiology， Zhengzhou People’s Hospital in Henan Province， Zhengzhou 450003， China
[Abstract] Objective To investigate the influences of danhong injection (DH) on tumor necrosis factor—α (TNF—α) and interleukin—6 (IL—6) of heart and cerebrum in aged rats. Methods All forty Wistar rats were randomly divided into the aging group， the Vit E group， the DH high—dose group and the DH low—dose group (n = 10). All the rats were handled according to the experimental design， the TNF—α and IL—6 of heart and cerebrum were detected by ELISA method. Results The TNF—α and IL—6 levels of the Vit E group， the DH high—dose group and the DH low—dose group were lower than those of the aging group (P < 0.05)； The TNF—α and IL—6 levels of the Vit E group， the DH high—dose group were lower than those of the DH low—dose group (P < 0.05). Conclusion DH can delay the aging in rats， maybe because it can reduce the inflammatory response.
[Key words] Danhong injection； Aging； Tumor necrosis factor—α； Interleukin—6
氧自由基损伤、细胞凋亡及炎症反应等均参与了大鼠衰老的发生发展过程，且各因素之间相互影响，或对促进衰老具有系统作用[1]。丹红注射液(DH)具有活血化瘀的作用 ......
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