乌司他丁联合利多卡因对大鼠肺缺血再灌注损伤的保护作用(1)
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[摘要] 目的 探讨乌司他丁联合利多卡因对大鼠肺缺血再灌注损伤时肿瘤坏死因子α(TNF-α)的影响。 方法 将120只Wistar大鼠随机分为5组。分别测定大鼠肺组织TNF-α表达水平、肺组织W/D值、动脉血气分析。 结果 与I/R组比较，S组、U组、L组及L+U组肺组织TNF-α表达水平均明显降低(P < 0.01)；肺组织W/D值明显降低(P < 0.01)；动脉血PaO2值差异有统计学意义(P < 0.01)。 结论 乌司他丁联合利多卡因对大鼠缺血再灌注急性肺损伤具有良好的保护作用，其机制可能与降低肺组织TNF-α表达水平有关。
[关键词] 再灌注损伤；利多卡因；乌司他丁；肿瘤坏死因子α
[中图分类号] R563 [文献标识码] B [文章编号] 1673-9701(2012)33-0024-03
Protective effects of ulinastatin combined with lidocaine on pulmonary ischemia reperfusion injury in rats
HUANG Zhigang GUO Guangwei CHANG Liang WEN Wen
Department of Cardiothoracic Surgery，the Second Hospital of Shanxi Medical University，Taiyuan 030001，China
[Abstract] Objective To explore the influence of ulinastatin combined with lidocaine on tumor necrosis factor alpha (TNF-α) on pulmonary， when the ischemia reperfusion injury occurred in rats. Methods A total of 120 Wistar rats were randomly divided into five groups. Measuring the level of rats lung tissue TNF-α expression， lung tissue W/D ratio、and arterial blood gas analysis. Results Compared with the I/R groups， S， U， L groups and L + U groups， the TNF-α expression levels were significantly lower(P < 0.01)；Lung tissue W/D was significantly lower(P < 0.01)；Arterial PaO2 values have statistically significant(P < 0.01). Conclusion Combining Lidocaine with ulinastatin administration has better protective effects on acute lung injury cased by ischemic reperfusion in rats， which probable mechanism is correlated with decreasing level of TNF-α.
[Key words] Reperfusion injury； Lidocaine； Ulinastatin； Tumor necrosis factor α
肺缺血/再灌注(Ischemia/Reperfusion，I/R)损伤常发生在肺移植、体外循环手术等临床情况下，造成肺缺血。重新灌注后，缺血引起的肺损伤不但不减轻，反而加重。进一步减轻肺I/R损伤，改善患者预后，是目前有待解决的关键问题。研究发现TNF-α在器官缺血再灌注损伤中具有关键作用 ......
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