重度子痫前期患者凝血功能的变化及意义(1)
[摘要] 目的 探讨凝血功能指标在重度子痫前期患者及正常妊娠妇女中的表达与意义。 方法 选择在我院就诊的重度子痫前期患者30例作为实验组，同期正常妊娠妇女40例为对照组，对两组进行凝血酶原时间(PT)、凝血酶原时间国际标准化比值(INR)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、D-二聚体(D-D)的检测，并用免疫比浊法进行血管性血友病因子(vWF)值检测，对比分析两组孕妇的妊娠结局。 结果 实验组PT、INR、APTT、及TT低于对照组，而D-D和vWF高于对照组，差异具有统计学意义(P<0.05)；实验组胎儿生长受限、早产率明显高于对照组。 结论 重度子痫前期孕妇血液呈高凝状态可导致不良妊娠结局，通过凝血指标及vWF的检测可以作为初步判断病情严重程度的指标之一。
[关键词] 重度子痫前期；凝血；血管性血友病因子；凝血酶原时间；活化部分凝血酶时间
[中图分类号] R714.2 [文献标识码] B [文章编号] 1673-9701(2018)17-0054-04
Changes and significance of coagulation function in the patients with severe preeclampsia
HU Yanjun LI Xiaoqing ZHENG Jiayong XIA Shuqi SHEN Xiaolu ZHANG Hongping
Department of Gynecology and Obstetrics， Wenzhou People's Hospital， Wenzhou Key Laboratory of Gynecology and Obstetrics， Wenzhou 325000， China
[Abstract] Objective To investigate the expression and significance of coagulation function parameters in the patients with severe preeclampsia and normal pregnant women. Methods 30 patients with severe preeclampsia who were treated in our hospital were selected as the experimental group. During the same period， 40 normal pregnant women were selected in the control group. Prothrombin time (PT)， international normalized ratio (INR) of prothrombin time， activated partial thrombin time (APTT)， thrombin time (TT)， and D-dimer(D-D) were measured in the two groups. The von Willebrand factor(vWF) value was detected by immunoturbidimetry and the pregnancy outcomes of pregnant women were analyzed and compared between the two groups. Results PT， INR， APTT， and TT were lower in the experimental group than in the control group. D-D and vWF were higher than the control group. The differences were statistically significant(P<0.05). The fetal growth restriction and premature birth rate in the experimental group were significantly higher than those in the control group. Conclusion The hypercoagulable state of blood in the pregnant women with severe preeclampsia may lead to adverse pregnancy outcomes. The detection of blood coagulation parameters and vWF can be used as one of the indicators for preliminarily judging the severity of disease.
[Key words] Severe preeclampsia； Coagulation； von Willebrand factor (VWF)； Prothrombin time (PT)； Activated partial thrombin time (APTT)
重度子癇前期是一种妊娠期特有的疾病，其主要临床特征是水肿、蛋白尿、高血压，由于血压和尿蛋白的持续升高，导致发生母体脏器功能不全或胎儿并发症，是引起孕产妇及胎儿围产期死亡的重要因素之一，严重危害着母婴的健康[1]。该疾病的发病机制目前尚未完全阐明[2]，但有研究发现，妊娠期孕产妇体内凝血功能的失衡状态与重度子痫前期的发生发展密切相关，一些凝血功能指标的异常改变在预测重度子痫前期疾病的发生发展中具有重要的作用[3]。本文通过检测孕晚期重度子痫前期患者和正常妊娠的孕晚期孕产妇的凝血功能指标的变化，来分析其在重度子痫前期疾病发生发展中的临床意义，现报道如下。, 百拇医药(胡艳君 李晓庆 郑加永 夏淑琦 沈晓露 张红萍)
[关键词] 重度子痫前期；凝血；血管性血友病因子；凝血酶原时间；活化部分凝血酶时间
[中图分类号] R714.2 [文献标识码] B [文章编号] 1673-9701(2018)17-0054-04
Changes and significance of coagulation function in the patients with severe preeclampsia
HU Yanjun LI Xiaoqing ZHENG Jiayong XIA Shuqi SHEN Xiaolu ZHANG Hongping
Department of Gynecology and Obstetrics， Wenzhou People's Hospital， Wenzhou Key Laboratory of Gynecology and Obstetrics， Wenzhou 325000， China
[Abstract] Objective To investigate the expression and significance of coagulation function parameters in the patients with severe preeclampsia and normal pregnant women. Methods 30 patients with severe preeclampsia who were treated in our hospital were selected as the experimental group. During the same period， 40 normal pregnant women were selected in the control group. Prothrombin time (PT)， international normalized ratio (INR) of prothrombin time， activated partial thrombin time (APTT)， thrombin time (TT)， and D-dimer(D-D) were measured in the two groups. The von Willebrand factor(vWF) value was detected by immunoturbidimetry and the pregnancy outcomes of pregnant women were analyzed and compared between the two groups. Results PT， INR， APTT， and TT were lower in the experimental group than in the control group. D-D and vWF were higher than the control group. The differences were statistically significant(P<0.05). The fetal growth restriction and premature birth rate in the experimental group were significantly higher than those in the control group. Conclusion The hypercoagulable state of blood in the pregnant women with severe preeclampsia may lead to adverse pregnancy outcomes. The detection of blood coagulation parameters and vWF can be used as one of the indicators for preliminarily judging the severity of disease.
[Key words] Severe preeclampsia； Coagulation； von Willebrand factor (VWF)； Prothrombin time (PT)； Activated partial thrombin time (APTT)
重度子癇前期是一种妊娠期特有的疾病，其主要临床特征是水肿、蛋白尿、高血压，由于血压和尿蛋白的持续升高，导致发生母体脏器功能不全或胎儿并发症，是引起孕产妇及胎儿围产期死亡的重要因素之一，严重危害着母婴的健康[1]。该疾病的发病机制目前尚未完全阐明[2]，但有研究发现，妊娠期孕产妇体内凝血功能的失衡状态与重度子痫前期的发生发展密切相关，一些凝血功能指标的异常改变在预测重度子痫前期疾病的发生发展中具有重要的作用[3]。本文通过检测孕晚期重度子痫前期患者和正常妊娠的孕晚期孕产妇的凝血功能指标的变化，来分析其在重度子痫前期疾病发生发展中的临床意义，现报道如下。, 百拇医药(胡艳君 李晓庆 郑加永 夏淑琦 沈晓露 张红萍)
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