卵巢交界性肿瘤12例临床病理分析(1)
[摘要] 目的 对卵巢交界性肿瘤的临床病理特征进行探讨。 方法 选择本院2013年5月～2018年1月期间12例卵巢交界性肿瘤住院患者手术切除经病理学确诊的病例，通过病理组织学观察进行研究，对卵巢交界性肿瘤的病理组织学特征进行分析。 结果 12例卵巢交界性肿瘤中6例为交界性浆液性肿瘤，4例为交界性黏液性肿瘤，1例为交界性子宫内膜样肿瘤，1例为交界性浆黏液性肿瘤，瘤细胞呈轻到中度的异型性，核染色质深，单层或复层排列，常<3层，结构上出现复杂分支状的乳头、绒毛状乳头或纤细的丝状乳头，可见密集的腺腔，具有纤维细胞少、水肿或玻璃样变的纤维脉管轴心。 结论 卵巢交界性肿瘤种类繁多，组织学特征性多样，必须充分取材，仔细观察，注意对微浸潤、上皮内癌和种植的诊断，以提高其诊断准确率 ，为临床诊治该疾病提供重要保证。
[关键词] 卵巢肿瘤；交界性肿瘤；病理特征；复发
[中图分类号] R737.31 [文献标识码] B [文章编号] 1673-9701(2018)23-0133-04
Clinicopathological analysis on 12 cases of borderline ovarian tumors
CHEN Youquan WEI Qing ZHANG Yurong CHEN Xiuming
Department of Pathology， Lu’an Second People’s Hospital in Anhui Province， Lu’an 237000， China
[Abstract] Objective To investigate the clinicopathological features of borderline ovarian tumors. Methods 12 hospitalized patients with borderline ovarian tumors who were given surgical resection and were diagnosed pathologically in our hospital from May 2013 to January 2018 were selected. The histopathological observation was performed to analyze the histopathological features of ovarian borderline tumors. Results Of the 12 cases of borderline ovarian tumors， 6 were borderline serous tumors， 4 cases were borderline mucinous tumors， one case was a borderline endometrioid tumor， and one case was a borderline mucinous tumor. The tumor cells showed a mild to moderate abnormality. Nuclear was in deep stain， arranged by single or multiple layers， with often <3 layers. Complex branching nipples， villous papilla， or slender filiform papillae were seen on the structure， and intensive glandular cavity was visible， with fibrous vascular axis with few fibroblasts， edema， or hyaline change. Conclusion There are many types of borderline ovarian tumors， and their histological characteristics are diverse. In order to improve its diagnostic accuracy， samples must be fully collected and carefully observed， then micro-invasion， intraepithelial carcinoma and planting should be given attention， which provide an important guarantee for clinical diagnosis and treatment of the disease.
[Key words] Ovarian tumors； Borderline tumors； Clinicopathological features； Relapses
卵巢肿瘤是妇科肿瘤中的常见类型，其形态变化多样，分类复杂，名称较多，卵巢上皮性细胞是卵巢最常见的肿瘤，约占58%，卵巢恶性肿瘤的90%，其中交界性肿瘤(Borderline ovarian tumors，BOTs)约占卵巢肿瘤的10%～20%，发病率也逐渐上升[1-3]，交界性肿瘤不同于浸润性卵巢癌，一般临床分期较早，预后较好，成为研究的重点，但交界性肿瘤组织学结构较复杂，在临床病理诊断中常带来困难，因此，正确认识和掌握交界性肿瘤的病理特征，显得尤其重要。本文就在我院诊治的12例卵巢交界性肿瘤的临床病理特征进行分析。
1 资料与方法
1.1 临床资料
取自2013年5月～2018年1月在本院行手术切除组织，术后病理诊断为卵巢交界性肿瘤的患者12例。患者年龄21～79岁，平均年龄49岁，其中<30岁1例、30～40岁3例、>41岁8例。左侧4 例，右侧6例，发生在双侧卵巢肿瘤2例。根据2013 FIGO分期标准，Ⅰ期9例，Ⅱ期2例，Ⅲ期1例。, http://www.100md.com(陈友权 魏清 张玉荣)
[关键词] 卵巢肿瘤；交界性肿瘤；病理特征；复发
[中图分类号] R737.31 [文献标识码] B [文章编号] 1673-9701(2018)23-0133-04
Clinicopathological analysis on 12 cases of borderline ovarian tumors
CHEN Youquan WEI Qing ZHANG Yurong CHEN Xiuming
Department of Pathology， Lu’an Second People’s Hospital in Anhui Province， Lu’an 237000， China
[Abstract] Objective To investigate the clinicopathological features of borderline ovarian tumors. Methods 12 hospitalized patients with borderline ovarian tumors who were given surgical resection and were diagnosed pathologically in our hospital from May 2013 to January 2018 were selected. The histopathological observation was performed to analyze the histopathological features of ovarian borderline tumors. Results Of the 12 cases of borderline ovarian tumors， 6 were borderline serous tumors， 4 cases were borderline mucinous tumors， one case was a borderline endometrioid tumor， and one case was a borderline mucinous tumor. The tumor cells showed a mild to moderate abnormality. Nuclear was in deep stain， arranged by single or multiple layers， with often <3 layers. Complex branching nipples， villous papilla， or slender filiform papillae were seen on the structure， and intensive glandular cavity was visible， with fibrous vascular axis with few fibroblasts， edema， or hyaline change. Conclusion There are many types of borderline ovarian tumors， and their histological characteristics are diverse. In order to improve its diagnostic accuracy， samples must be fully collected and carefully observed， then micro-invasion， intraepithelial carcinoma and planting should be given attention， which provide an important guarantee for clinical diagnosis and treatment of the disease.
[Key words] Ovarian tumors； Borderline tumors； Clinicopathological features； Relapses
卵巢肿瘤是妇科肿瘤中的常见类型，其形态变化多样，分类复杂，名称较多，卵巢上皮性细胞是卵巢最常见的肿瘤，约占58%，卵巢恶性肿瘤的90%，其中交界性肿瘤(Borderline ovarian tumors，BOTs)约占卵巢肿瘤的10%～20%，发病率也逐渐上升[1-3]，交界性肿瘤不同于浸润性卵巢癌，一般临床分期较早，预后较好，成为研究的重点，但交界性肿瘤组织学结构较复杂，在临床病理诊断中常带来困难，因此，正确认识和掌握交界性肿瘤的病理特征，显得尤其重要。本文就在我院诊治的12例卵巢交界性肿瘤的临床病理特征进行分析。
1 资料与方法
1.1 临床资料
取自2013年5月～2018年1月在本院行手术切除组织，术后病理诊断为卵巢交界性肿瘤的患者12例。患者年龄21～79岁，平均年龄49岁，其中<30岁1例、30～40岁3例、>41岁8例。左侧4 例，右侧6例，发生在双侧卵巢肿瘤2例。根据2013 FIGO分期标准，Ⅰ期9例，Ⅱ期2例，Ⅲ期1例。, http://www.100md.com(陈友权 魏清 张玉荣)