体外受精-胚胎移植受孕的试管婴儿与自然分娩新生儿围生结局比较(1)
[摘要] 目的 比較体外受精-胚胎移植(IVF-ET)受孕的试管婴儿与自然分娩新生儿围生结局。 方法 回顾性收集2017年6月～2019年7月于我院接受IVF-ET受孕的孕产妇72例为观察组，另选取同期自然受孕分娩的孕产妇63例为对照组，比较两组孕产妇妊娠期情况、新生儿出生缺陷及并发症情况。 结果 观察组孕产妇平均年龄为(33.58±4.20)岁，高于对照组的(28.61±3.75)岁(P<0.05)，观察组孕产妇平均分娩孕周为(38.05±2.20)周，少于对照组的(39.05±1.22)周(P<0.05)，观察组孕产妇妊高症、妊娠期糖尿病、多胎、早产、剖宫产发生率均高于对照组(P<0.05)，两组胎膜早破、羊水异常、前置胎盘、胎儿宫内窘迫发生率比较，差异均无统计学意义(P>0.05);观察组新生儿先天畸形、心脏畸形发生率高于对照组(P<0.05)，两组新生儿食管闭锁、肛门闭锁、尿道下裂、唇腭裂、多指(趾)、开放性脊柱裂、组织器官不全发生率比较，差异均无统计学意义(P>0.05);观察组新生儿高胆红素血症、呼吸窘迫综合征发生率高于对照组(P<0.05)，两组低血糖、肺炎、新生儿窒息、颅内出血、肺出血、呼吸暂停发生率比较，差异均无统计学意义(P>0.05)。 结论 相较于自然受孕的新生儿，IVF-ET受孕的试管婴儿生理结构缺陷率、围生期疾病发生率相对较高。
[关键词] 体外受精-胚胎移植;自然受孕;试管婴儿;出生缺陷;围生结局
[中图分类号] R714.8 [文献标识码] B [文章编号] 1673-9701(2020)07-0066-03
Comparison of perinatal outcomes between IVF-ET and natural conception
YAN Xiqiu
Department of Reproductive Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi 154002， China
[Abstract] Objective To compare the perinatal outcomes of in vitro fertilization-embryo transfer (IVF-ET) and natural birth. Methods A total of 72 cases of pregnant women who received IVF-ET in our hospital from June 2017 to July 2019 were collected as the observation group and retrospectively analyzed. And 63 cases of pregnant women who gave birth naturally during the same period were selected as the control group. The maternal pregnancy， neonatal birth defects and complications were compared between the two groups were compared. Results The average maternal age in the observation group was (33.58±4.20) years，which was higher than that in the control group [(28.61±3.75) years] (P< 0.05). The delivery gestational age in the observation group was (38.05±2.20) weeks， which was shorter than that in the control group[(39.05±1.22) weeks](P<0.05). The incidence of pregnancy-induced hypertension， gestational diabetes mellitus， multiple births， preterm delivery， and cesarean delivery in the observation group were higher than those in the control group(P<0.05). There were no significant differences in the incidence of premature rupture of membranes， abnormal amniotic fluid， placenta previa， and intrauterine distress between the two groups(P>0.05). The incidence of congenital malformations and cardiac malformations in the observation group was higher than in the control group(P<0.05). There was no significant difference in the incidence of esophageal atresia， anal atresia， hypospadias， cleft lip and palate， multi-finger (toe)， open spina bifida， and tissue and organ insufficiency between the two groups(P>0.05). The incidence of neonatal hyperbilirubinemia and respiratory distress syndrome in the observation group was higher than that in the control group(P<0.05). The incidence of hypoglycemia， pneumonia， neonatal asphyxia， intracranial hemorrhage， pulmonary hemorrhage， and apnea was compared between the two groups， and the differences were not statistically significant(P>0.05). Conclusion Compared with natural birth， the IVF-ET neonatal has a relatively high rate of physiological structural defects and perinatal diseases., http://www.100md.com(闫喜秋)
[关键词] 体外受精-胚胎移植;自然受孕;试管婴儿;出生缺陷;围生结局
[中图分类号] R714.8 [文献标识码] B [文章编号] 1673-9701(2020)07-0066-03
Comparison of perinatal outcomes between IVF-ET and natural conception
YAN Xiqiu
Department of Reproductive Medicine， Jiamusi Maternal and Child Health Hospital in Heilongjiang Province， Jiamusi 154002， China
[Abstract] Objective To compare the perinatal outcomes of in vitro fertilization-embryo transfer (IVF-ET) and natural birth. Methods A total of 72 cases of pregnant women who received IVF-ET in our hospital from June 2017 to July 2019 were collected as the observation group and retrospectively analyzed. And 63 cases of pregnant women who gave birth naturally during the same period were selected as the control group. The maternal pregnancy， neonatal birth defects and complications were compared between the two groups were compared. Results The average maternal age in the observation group was (33.58±4.20) years，which was higher than that in the control group [(28.61±3.75) years] (P< 0.05). The delivery gestational age in the observation group was (38.05±2.20) weeks， which was shorter than that in the control group[(39.05±1.22) weeks](P<0.05). The incidence of pregnancy-induced hypertension， gestational diabetes mellitus， multiple births， preterm delivery， and cesarean delivery in the observation group were higher than those in the control group(P<0.05). There were no significant differences in the incidence of premature rupture of membranes， abnormal amniotic fluid， placenta previa， and intrauterine distress between the two groups(P>0.05). The incidence of congenital malformations and cardiac malformations in the observation group was higher than in the control group(P<0.05). There was no significant difference in the incidence of esophageal atresia， anal atresia， hypospadias， cleft lip and palate， multi-finger (toe)， open spina bifida， and tissue and organ insufficiency between the two groups(P>0.05). The incidence of neonatal hyperbilirubinemia and respiratory distress syndrome in the observation group was higher than that in the control group(P<0.05). The incidence of hypoglycemia， pneumonia， neonatal asphyxia， intracranial hemorrhage， pulmonary hemorrhage， and apnea was compared between the two groups， and the differences were not statistically significant(P>0.05). Conclusion Compared with natural birth， the IVF-ET neonatal has a relatively high rate of physiological structural defects and perinatal diseases., http://www.100md.com(闫喜秋)
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