四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡效果探讨(1)
[摘要] 目的 通过观察四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡的效果，分析探讨四联疗法在治疗这种疾病中是否值得在临床上推广。 方法 选取2011年4月—2014年4月期间在该院接受治疗的幽门螺杆菌阳性十二指肠球部溃疡患者94例，并将这94例患者随机平均分为实验组47例和对照组47例，对实验组的患者使用四联疗法治疗，对对照组的患者使用三联疗法治疗，比较两组的治疗成效和不良反应。 结果 实验组患者在接受治疗后，幽门螺杆菌的根除率为91.5%，溃疡愈合率为95.7%，都明显高于对照组的幽门螺杆菌的根除率80.6%和溃疡愈合率83.0%，而且实验组患者在治疗中不良反应的发生率为6.4%，也明显低于对照组23.4%。 结论 采用四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡疾病效果明显，而且不良反应发生率低，在临床上推广使用具有重大意义。
[关键词] 四联疗法；幽门螺杆菌阳性十二指肠球部溃疡；治疗效果
[中图分类号] R57 [文献标识码] A [文章编号] 1674-0742(2015)03(a)-0003-02
Observation of the Effect of Quadruple Therapy on Helicobacter Pylori-positive Duodenal Ulcer
HUANG Cuihua
Department of Internal Medicine， First People's Hospital of Xuanwei， Xuanwei， Yunnan Province， 655400， China
[Abstract] Objective To analyze whether the quadruple therapy for Helicobacter pylori-positive duodenal ulcer is worth promoting in clinical practice by observing its effect on the disease. Methods 94 cases with Helicobacter pylori-positive duodenal ulcer treated in our hospital from April 2011 to April 2014 were selected and randomly and equally divided into the experimental group 47 cases and the control group 47 cases. The experimental group were treated by quadruple therapy while the control group were treated by triple therapy. And the treatment effect and adverse reactions were compared between the two groups. Results After treatment， in the experimental group， the eradication rate of Helicobacter pylori was obviously higher than that in the control group(91.5% versus 80.6%)， the ulcer healing rate was significantly higher than that in the control group(95.7% versus 83.0%)， the incidence of adverse reactions during the treatment was much lower than that in the control group(6.4% versus 23.4%). Conclusion For Helicobacter pylori-positive duodenal ulcer， quadruple therapy is of great clinical promotion significance because it has significant effect with low incidence of adverse reactions.
[Key words] Quadruple therapy； Helicobacter pylori-positive duodenal ulcer； Treatment effect
十二指肠球部溃疡是胃肠道疾病中的常见疾病，这种疾病的发病主要是被幽门螺杆菌感染造成的[1]。所以在治疗中，主要就是将幽门螺杆菌根除。为通过观察四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡的效果，分析四联疗法在治疗这种疾病中是否值得在临床上推广，该研究选取2011年4月—2014年4月期间对该院收治的47例幽门螺杆菌阳性十二指肠球部溃疡患者使用四联疗法进行治疗的效果进行分析，结果令人较为满意，现报道如下。
1 资料与方法
1.1 一般资料
选取在该院接受治疗的幽门螺杆菌阳性十二指肠球部溃疡患者94例，并将这94例患者随机平均分为实验组47例和对照组47例，实验组男32例，女15例，年龄20～70岁之间，平均年龄(45.6±12.7)岁，病程1个月～2年；对照组患者男29例，女18例，年龄21～69岁之间，平均年龄(46.2±9.8)岁，病程1个月～2年。两组患者的溃疡直径均超过了4 mm。
1.2 治疗方法
1.2.1 对照组 对对照组的患者均使用三联疗法，枸橼酸铋钾120 mg，阿莫西林250 mg，甲硝唑400 mg，服药2次/d，每次3种药物按剂量同时服用，连续服药2周。在服药期间禁吃辛辣食物。, 百拇医药(黄翠华)
[关键词] 四联疗法；幽门螺杆菌阳性十二指肠球部溃疡；治疗效果
[中图分类号] R57 [文献标识码] A [文章编号] 1674-0742(2015)03(a)-0003-02
Observation of the Effect of Quadruple Therapy on Helicobacter Pylori-positive Duodenal Ulcer
HUANG Cuihua
Department of Internal Medicine， First People's Hospital of Xuanwei， Xuanwei， Yunnan Province， 655400， China
[Abstract] Objective To analyze whether the quadruple therapy for Helicobacter pylori-positive duodenal ulcer is worth promoting in clinical practice by observing its effect on the disease. Methods 94 cases with Helicobacter pylori-positive duodenal ulcer treated in our hospital from April 2011 to April 2014 were selected and randomly and equally divided into the experimental group 47 cases and the control group 47 cases. The experimental group were treated by quadruple therapy while the control group were treated by triple therapy. And the treatment effect and adverse reactions were compared between the two groups. Results After treatment， in the experimental group， the eradication rate of Helicobacter pylori was obviously higher than that in the control group(91.5% versus 80.6%)， the ulcer healing rate was significantly higher than that in the control group(95.7% versus 83.0%)， the incidence of adverse reactions during the treatment was much lower than that in the control group(6.4% versus 23.4%). Conclusion For Helicobacter pylori-positive duodenal ulcer， quadruple therapy is of great clinical promotion significance because it has significant effect with low incidence of adverse reactions.
[Key words] Quadruple therapy； Helicobacter pylori-positive duodenal ulcer； Treatment effect
十二指肠球部溃疡是胃肠道疾病中的常见疾病，这种疾病的发病主要是被幽门螺杆菌感染造成的[1]。所以在治疗中，主要就是将幽门螺杆菌根除。为通过观察四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡的效果，分析四联疗法在治疗这种疾病中是否值得在临床上推广，该研究选取2011年4月—2014年4月期间对该院收治的47例幽门螺杆菌阳性十二指肠球部溃疡患者使用四联疗法进行治疗的效果进行分析，结果令人较为满意，现报道如下。
1 资料与方法
1.1 一般资料
选取在该院接受治疗的幽门螺杆菌阳性十二指肠球部溃疡患者94例，并将这94例患者随机平均分为实验组47例和对照组47例，实验组男32例，女15例，年龄20～70岁之间，平均年龄(45.6±12.7)岁，病程1个月～2年；对照组患者男29例，女18例，年龄21～69岁之间，平均年龄(46.2±9.8)岁，病程1个月～2年。两组患者的溃疡直径均超过了4 mm。
1.2 治疗方法
1.2.1 对照组 对对照组的患者均使用三联疗法，枸橼酸铋钾120 mg，阿莫西林250 mg，甲硝唑400 mg，服药2次/d，每次3种药物按剂量同时服用，连续服药2周。在服药期间禁吃辛辣食物。, 百拇医药(黄翠华)