不同剂量瑞舒伐他汀钙在老年冠心病合并高脂血症治疗中的临床疗效对比分析(1)
[摘要] 目的 对比分析不同剂量瑞舒伐他汀钙治疗老年冠心病合并高脂血症的疗效。 方法 整群选取该院2014年8月—2015年8月期间收治的老年冠心病合并高脂血症患者93例，分为3组，每组31例，A组用5 mg瑞舒伐他汀钙治疗，B组用15 mg瑞舒伐他汀钙治疗，C组用20 mg瑞舒伐他汀钙治疗，分析3组治疗效果。 结果 C组TG、LDL-C下降程度、HDL-C上升程度优于A、B两组(P<0.05)；且C组总有效率高于A、B两组(P<0.05)；但3组不良反应比较差异无统计学意义(P>0.05)。 结论 采用20 mg瑞舒伐他汀钙治疗老年冠心病合并高脂血症的临床疗效显著，值得推广。
[关键词] 不同剂量；瑞舒伐他汀钙；老年冠心病合并高脂血症
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2016)02(c)-0121-02
Comparison of Clinical Curative Effect of Different Doses of Rosuvastatin Clcium in Treatment of Coronary Heart Disease in Elderly Combined with Hyperlipemia
LIN Zhao-yang， LIN Mao-mei
Pharmacy Department， Putian First Hospital of Fujian Province， 351100 China
[Abstract] Objective To comparatively analyze the curative effect of different doses of rosuvastatin calcium？in treatment of coronary heart disease in elderly combined with hyperlipemia. Methods 93 cases of patients with coronary heart disease in elderly combined with hyperlipemia admitted and treated in our hospital from August 2014 to August 2015 were selected and divided into three groups， the group A were treated with 5mg rosuvastatin calcium， the group B were treated with 15mg rosuvastatin calcium， the group C were treated with 20mg rosuvastatin calcium， the treatment effect of the three groups was analyzed. Results The descending degree of TG and LDL-C and rising degree of HDL-C in the group C were better than those in the group A and the group B，(P<0.05)， the total effective rate in the group C was higher than that in the group A and the group B，(P<0.05)， but there was no obvious difference between the three groups by comparison(P>0.05). Conclusion The clinical curative effect of 20mg rosuvastatin calcium？in treatment of coronary heart disease in elderly combined with hyperlipemia is obvious， which is worth promotion.
[Key words] Different doses； Rosuvastatin calcium； Coronary heart disease in elderly combined with hyperlipemia
冠心病是心血管科常见疾病，该病多疑冠状动脉粥样硬化所致。近年来，随着医疗模式的日趋完善，越来越多的研究认为血脂异常是引发冠心病发展最为主要的因素[1]。瑞舒伐他汀钙在抑制动脉粥样硬化的进展、降低血脂方面具有积极意义，但不同剂量瑞舒伐他汀钙，其降脂、稳定斑块的效果不同[2]。本文主要研究该院2014年8月—2015年8月采用不同剂量瑞舒伐他汀钙治疗93例老年冠心病合并高脂血症的临床疗效，现报道如下。
1 资料与方法
1.1 一般资料
整群选取2014年8月—2015年8月期间该院接收并治疗的老年冠心病合并高脂血症患者中93例，男性占50例，女性占43例；患者年龄为61～79岁，平均年龄(67±1.26)岁；病程为1～10年，平均病程(6±1.01)年。根据用药剂量进行分组，其中，采用5 mg瑞舒伐他汀钙治疗的31例为A组，采用15 mg瑞舒伐他汀钙治疗的31例为B组，采用20 mg瑞舒伐他汀钙治疗的31例为C组；3组在年龄层次、性别比等方面的比较差异无统计学业意义(P>0.05)，可对比研究。
1.2 治疗方法
3组患者入院后，均行常规硝酸甘油、阿司匹林以及血管紧张素转化酶抑制剂等治疗，在此基础上，给予A组5 mg瑞舒伐他汀钙(国药准字为：H20133018)治疗，1次/d；B组采用15 mg瑞舒伐他汀钙治疗，1次/d；C组采用20 mg瑞舒伐他汀钙治疗，1次/d；治疗3周为1个疗程，3组均连续治疗4个疗程。 (林朝阳 林茂梅)
[关键词] 不同剂量；瑞舒伐他汀钙；老年冠心病合并高脂血症
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2016)02(c)-0121-02
Comparison of Clinical Curative Effect of Different Doses of Rosuvastatin Clcium in Treatment of Coronary Heart Disease in Elderly Combined with Hyperlipemia
LIN Zhao-yang， LIN Mao-mei
Pharmacy Department， Putian First Hospital of Fujian Province， 351100 China
[Abstract] Objective To comparatively analyze the curative effect of different doses of rosuvastatin calcium？in treatment of coronary heart disease in elderly combined with hyperlipemia. Methods 93 cases of patients with coronary heart disease in elderly combined with hyperlipemia admitted and treated in our hospital from August 2014 to August 2015 were selected and divided into three groups， the group A were treated with 5mg rosuvastatin calcium， the group B were treated with 15mg rosuvastatin calcium， the group C were treated with 20mg rosuvastatin calcium， the treatment effect of the three groups was analyzed. Results The descending degree of TG and LDL-C and rising degree of HDL-C in the group C were better than those in the group A and the group B，(P<0.05)， the total effective rate in the group C was higher than that in the group A and the group B，(P<0.05)， but there was no obvious difference between the three groups by comparison(P>0.05). Conclusion The clinical curative effect of 20mg rosuvastatin calcium？in treatment of coronary heart disease in elderly combined with hyperlipemia is obvious， which is worth promotion.
[Key words] Different doses； Rosuvastatin calcium； Coronary heart disease in elderly combined with hyperlipemia
冠心病是心血管科常见疾病，该病多疑冠状动脉粥样硬化所致。近年来，随着医疗模式的日趋完善，越来越多的研究认为血脂异常是引发冠心病发展最为主要的因素[1]。瑞舒伐他汀钙在抑制动脉粥样硬化的进展、降低血脂方面具有积极意义，但不同剂量瑞舒伐他汀钙，其降脂、稳定斑块的效果不同[2]。本文主要研究该院2014年8月—2015年8月采用不同剂量瑞舒伐他汀钙治疗93例老年冠心病合并高脂血症的临床疗效，现报道如下。
1 资料与方法
1.1 一般资料
整群选取2014年8月—2015年8月期间该院接收并治疗的老年冠心病合并高脂血症患者中93例，男性占50例，女性占43例；患者年龄为61～79岁，平均年龄(67±1.26)岁；病程为1～10年，平均病程(6±1.01)年。根据用药剂量进行分组，其中，采用5 mg瑞舒伐他汀钙治疗的31例为A组，采用15 mg瑞舒伐他汀钙治疗的31例为B组，采用20 mg瑞舒伐他汀钙治疗的31例为C组；3组在年龄层次、性别比等方面的比较差异无统计学业意义(P>0.05)，可对比研究。
1.2 治疗方法
3组患者入院后，均行常规硝酸甘油、阿司匹林以及血管紧张素转化酶抑制剂等治疗，在此基础上，给予A组5 mg瑞舒伐他汀钙(国药准字为：H20133018)治疗，1次/d；B组采用15 mg瑞舒伐他汀钙治疗，1次/d；C组采用20 mg瑞舒伐他汀钙治疗，1次/d；治疗3周为1个疗程，3组均连续治疗4个疗程。 (林朝阳 林茂梅)