氰尿酸诱导孕鼠形成肾结石动物模型的研究(3)
综上所述，通过该实验得出的结果说明氰尿酸作为三聚氰胺的类似物，对人类的确有一定的危害，需要我们继续对其研究，目前对于三聚氰胺、氰尿酸的成石机制还未完全清楚，该实验通过给妊娠雌鼠灌胃摄入氰尿酸的方法，成功建立了氰尿酸孕鼠尿路结石的模型，为氰尿酸尿路结石合并妊娠的预防和治疗提供实验依据。并且应用氰尿酸建立孕鼠尿路结石动物模型尚属首创，类似动物模型国内外研究较少，通过观察孕鼠的生长及生产情况，对预测氰尿酸对妊娠妇女的影响也同样具有重大意义。
[参考文献]
[1] Dorne JL，Doerge DR，Vandenbroeck M，et al.Recent advance in the risk assessment of melamine and cyanuric acid in animal feed[J].Toxicol Appl Pharmacol，2013，270(3)：218-229.
[2] Kim GH，Kang MJ，Noh K，et al.Nephrotoxic potential and toxicokinetics of melamine combined with cyanuric acid in rats[J].J Toxicol Environ Health A，2014，77(22-24)：1346-1358.
[3] Hodge HC，Panner BJ，Downs WL，et a1.Toxicity of sodium cyanurate[J].Toxicol Appl Pharmacol，1965，7(5)：667-674.
[4] Ji Yeon Son，Yoon Jong Kang，Kyeong Seok Kim，et al.Evaluation of renal toxicity by combination exposure to melamine and cyanuric acid in male sprague-dawley rats[J].Toxicol Res，2014，30(2)：99-107.
[5] Stine CB，Reimschuessel R，Keltner Z，et al.Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid[J].Food Chem Toxicol，2014，68：142-153.
[6] Chen YT，Jiann BP，Wu CH，et al.Kidney stone distribution caused by melamine and cyanuric acid in rats[J].Clin Chim Acta，2014，430：96-103.
[7] Bob Weinhold.Gut bacteria and melamine toxicity[J].Environ Health Perspect，2013，121(5)：149.
[8] Yin RH，Liu J，Li HS，et al.The toxic effects of melamine on spleen lymphocytes with or without cyanuric acid in mice[J].Res Vet Sci，2014，97(3)：505-513.
(收稿日期：2015-12-07) (刘迪 吴希庆 萨音白刚 杨建新)
[参考文献]
[1] Dorne JL，Doerge DR，Vandenbroeck M，et al.Recent advance in the risk assessment of melamine and cyanuric acid in animal feed[J].Toxicol Appl Pharmacol，2013，270(3)：218-229.
[2] Kim GH，Kang MJ，Noh K，et al.Nephrotoxic potential and toxicokinetics of melamine combined with cyanuric acid in rats[J].J Toxicol Environ Health A，2014，77(22-24)：1346-1358.
[3] Hodge HC，Panner BJ，Downs WL，et a1.Toxicity of sodium cyanurate[J].Toxicol Appl Pharmacol，1965，7(5)：667-674.
[4] Ji Yeon Son，Yoon Jong Kang，Kyeong Seok Kim，et al.Evaluation of renal toxicity by combination exposure to melamine and cyanuric acid in male sprague-dawley rats[J].Toxicol Res，2014，30(2)：99-107.
[5] Stine CB，Reimschuessel R，Keltner Z，et al.Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid[J].Food Chem Toxicol，2014，68：142-153.
[6] Chen YT，Jiann BP，Wu CH，et al.Kidney stone distribution caused by melamine and cyanuric acid in rats[J].Clin Chim Acta，2014，430：96-103.
[7] Bob Weinhold.Gut bacteria and melamine toxicity[J].Environ Health Perspect，2013，121(5)：149.
[8] Yin RH，Liu J，Li HS，et al.The toxic effects of melamine on spleen lymphocytes with or without cyanuric acid in mice[J].Res Vet Sci，2014，97(3)：505-513.
(收稿日期：2015-12-07) (刘迪 吴希庆 萨音白刚 杨建新)