盐酸羟考酮注射液复合丙泊酚麻醉用于老年患者内镜下逆行胰胆管造影术疗效和安全性(1)
[摘要] 目的 研究内镜下逆行胰胆管造影术(ERCP)老年患者行盐酸羟考酮复合丙泊酚的麻醉效果及安全性。 方法 整群选取112例该院2013年4月—2015年4月期间行ERCP的老年患者，将所有患者按随机数字表法分为两组各56例。其中56例患者术中采用芬太尼复合丙泊酚进行麻醉作为对照组，另56例患者术中采用盐酸羟考酮复合丙泊酚进行麻醉作为观察组。观察两组患者血流动力、手术情况以及不良反应情况。结果 两组患者各时段HR、MAP以及SpO2对比无差异，P>0.05。观察组丙泊酚用量、手术时间、苏醒时间以及术后VAS评分分别为(169.4±15.8)mg、(33.2±5.8)min、(6.5±2.2)min以及(3.4±0.7)分，均明显优于对照组的(131.2±13.4)mg、(28.7±7.3)min、(5.6±2.1)min以及(2.1±0.4)分，P<0.05。观察组不良反应发生率3.57%，明显低于对照组的14.29%，P<0.05。结论 老年患者ERCP术中采用羟考酮复合丙泊酚麻醉可有效控制血流动力稳定，缩短手术过程，减轻疼痛，降低不良反应，保障患者安全，值得临床应用及推广。
[关键词] 麻醉；丙泊酚；盐酸羟考酮；胰胆管造影术；疗效；安全性
[中图分类号] R614 [文献标识码] A [文章编号] 1674-0742(2016)03(c)-0140-03
Curative Effect and Security of Oxycodone Hydrochloride Injection Combined with Propofol Anaesthesia in Endoscopic Retrograde Cholangiopancreatography for Senile Patients
SHAO Jian-jun， DONG Yong-jie
Department of Anesthesiology， Baotou Eighth Hospital， Baotou， Inner Mongolia， 014040 China
[Abstract] Objective To research the effect and security of oxycodone hydrochloride injection combined with propofol anaesthesia in endoscopic retrograde cholangiopancreatography for senile patients. Methods 112 cases of senile patients with ERCP treated in our hospital from April 2013 to April 2015 were selected and randomly divided into two groups with 56 cases in each， the control group were given fentanyl combined with propofol for anaesthesia， the observation group were given oxycodone hydrochloride combined with propofol for anaesthesia， the hemodynamics， operation conditions and adverse reactions of the two groups were observed. Results There was no difference in the HR， MAP and SpO2 in each period between the two groups， P>0.05， the dosage of propofol， operation time， wake-up time and postoperative VAS score in the observation group were obviously better than those in the control group， [(169.4±15.8) mg， (33.2±5.8) min， (6.5±2.2) min， (3.4±0.7) points vs (131.2±13.4) mg， (28.7±7.3) min， (5.6±2.1) min， (2.1±0.4) points]，P<0.05， the incidence rate of adverse reaction in the observation group was obviously lower than that in the control group， (3.57% vs 14.29%)， P<0.05. Conclusion Oxycodone hydrochloride injection combined with propofol anaesthesia in ERCP for senile patients can effectively stabilize the hemodynamics， shorten the operation process， relieve the pains， reduce the adverse reactions and ensure the patient’s security， which is worth clinical application and promotion.
[Key words] Anaesthesia； Propofol； Oxycodone hydrochloride； Cholangiopancreatography； Curative effect； Security (邵建军 懂勇杰)
[关键词] 麻醉；丙泊酚；盐酸羟考酮；胰胆管造影术；疗效；安全性
[中图分类号] R614 [文献标识码] A [文章编号] 1674-0742(2016)03(c)-0140-03
Curative Effect and Security of Oxycodone Hydrochloride Injection Combined with Propofol Anaesthesia in Endoscopic Retrograde Cholangiopancreatography for Senile Patients
SHAO Jian-jun， DONG Yong-jie
Department of Anesthesiology， Baotou Eighth Hospital， Baotou， Inner Mongolia， 014040 China
[Abstract] Objective To research the effect and security of oxycodone hydrochloride injection combined with propofol anaesthesia in endoscopic retrograde cholangiopancreatography for senile patients. Methods 112 cases of senile patients with ERCP treated in our hospital from April 2013 to April 2015 were selected and randomly divided into two groups with 56 cases in each， the control group were given fentanyl combined with propofol for anaesthesia， the observation group were given oxycodone hydrochloride combined with propofol for anaesthesia， the hemodynamics， operation conditions and adverse reactions of the two groups were observed. Results There was no difference in the HR， MAP and SpO2 in each period between the two groups， P>0.05， the dosage of propofol， operation time， wake-up time and postoperative VAS score in the observation group were obviously better than those in the control group， [(169.4±15.8) mg， (33.2±5.8) min， (6.5±2.2) min， (3.4±0.7) points vs (131.2±13.4) mg， (28.7±7.3) min， (5.6±2.1) min， (2.1±0.4) points]，P<0.05， the incidence rate of adverse reaction in the observation group was obviously lower than that in the control group， (3.57% vs 14.29%)， P<0.05. Conclusion Oxycodone hydrochloride injection combined with propofol anaesthesia in ERCP for senile patients can effectively stabilize the hemodynamics， shorten the operation process， relieve the pains， reduce the adverse reactions and ensure the patient’s security， which is worth clinical application and promotion.
[Key words] Anaesthesia； Propofol； Oxycodone hydrochloride； Cholangiopancreatography； Curative effect； Security (邵建军 懂勇杰)