甘精胰岛素联合阿卡波糖治疗2型糖尿病的疗效观察(1)
[摘要] 目的 探讨甘精胰岛素联合阿卡波糖治疗2型糖尿病的临床效果。方法 方便选取2012年10月—2013年12月期间在该院收治的2型糖尿病患者100例，随机分为研究组和对照组(每组50例)。研究组采用甘精胰岛素联合阿卡波糖治疗，对照组给予预混胰岛素(诺和灵30R)治疗。治疗周期均为12周，治疗后观察两组治患者空腹血糖(FBG)、餐后2 h血糖(2 h PBG)糖化血红蛋白(HbAlc)的变化、低血糖发生率及胃肠道不良反应。结果 两组治疗后患者FBG、2 h PBG HbAlc均明显降低，其中治疗后两组FBG，HbAlc水平比较差异无统计学意义(P>0.05)，两组患者2 h PBG水平比较差异具有统计学意义(P<0.05)；研究组和对照组低血糖发生率分别为3例(6.0%)和10例(20.0%)，两组比较差异具有统计学意义(P<0.05)。结论 甘精胰岛素联合阿卡波糖能较好的控制2型糖尿病患者的血糖，且患者低血糖发生率低，值得临床推广使用。
[关键词] 甘精胰岛素；阿卡波糖；2型糖尿病
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-0742(2016)08(c)-0148-03
Efficacy of Insulin Glargine Combined with Acarbose Treatment of Type 2 Diabetes
CHEN Hui-chen，QIAN Wan-qiao
Xili， Nanshan District， Shenzhen People's Hospital Pharmaceutical Affairs Ministry， Shenzhen，Guangdong Province， 518055 China
[Abstract] Objective To investigate the insulin glargine combined with the clinical effect of acarbose in type 2 diabetes. Methods Convenient selection from October 2012 to December 2013 in our hospital treated 100 patients with type 2 diabetes were randomly divided into study group and control group(n = 50). Study group received insulin glargine combined with acarbose treatment， control group received premixed insulin (Novolin 30R) treatment. Treatment period is 12 weeks after treatment were observed treatment of patients fasting blood glucose(FBG)， postprandial 2 h glucose adverse reactions (2 h PBG) glycated hemoglobin (HbAlc) changes in the incidence of hypoglycemia and gastrointestinal tract. Results After treatment， patients FBG， 2 h PBG HbAlc were significantly decreased in both groups after which treatment FBG， HbAlc level difference was not statistically significant(P> 0.05)， two groups of patients 2 h PBG level and the difference was statistically significant(P <0.05 )； the study group and the control group， the incidence of hypoglycemia were 3 cases (6.0%) and 10 patients (20.0%)， the difference was statistically significant (P <0.05). Conclusion Insulin Glargine combined acarbose can better glucose control in type 2 diabetes， and the incidence of hypoglycemia in patients with low， worthy of clinical use.
[Key words] Insulin insulin； Acarbose； Type 2 diabetes mellitus
2型糖尿病(type 2 diabetes melitus，T2DM)是一种以长期高血糖为特征进行性代谢紊乱疾病，近年来随着人民生活水平的提高在我国发病率呈逐年上升趋势，长期高血糖可引起血管及神经病变，导致严重的大血管，微血管并发症的发生[1]。该院自2012年10月—2013年12月采用采用甘精胰岛素联合阿卡波糖对100例T2DM患者进行了治疗，取得了较好的效果，现报道如下。
1 材料与方法
1.1 一般资料
方便选择在该院门诊及住院T2DM患者100例，其中，所有患者均符合WHO1999年2型糖尿病诊断标准。排除标准：①严重的心脏疾患及肝肾功能异常；②合并泌尿系、呼吸道等严重感染；③妊娠、哺乳妇女；④继发糖尿病；⑤曾服用过可能影响血糖的药物(如糖皮质激素等)的病患者[2]。所有患者随机分为研究组及对照组，每组各50例，其中研究组男29例，女21例，患者年龄35～76岁，平均(49.8±7.4)岁。病程4～8年，平均(5.9±1.6)年；对照组男31例，女19例，患者年龄34～79岁，平均(46.1±5.6)岁。病程3～7年，平均(5.2±1.4)年。两组间性别，年龄，病程等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (陈穗琛 钱万桥)
[关键词] 甘精胰岛素；阿卡波糖；2型糖尿病
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-0742(2016)08(c)-0148-03
Efficacy of Insulin Glargine Combined with Acarbose Treatment of Type 2 Diabetes
CHEN Hui-chen，QIAN Wan-qiao
Xili， Nanshan District， Shenzhen People's Hospital Pharmaceutical Affairs Ministry， Shenzhen，Guangdong Province， 518055 China
[Abstract] Objective To investigate the insulin glargine combined with the clinical effect of acarbose in type 2 diabetes. Methods Convenient selection from October 2012 to December 2013 in our hospital treated 100 patients with type 2 diabetes were randomly divided into study group and control group(n = 50). Study group received insulin glargine combined with acarbose treatment， control group received premixed insulin (Novolin 30R) treatment. Treatment period is 12 weeks after treatment were observed treatment of patients fasting blood glucose(FBG)， postprandial 2 h glucose adverse reactions (2 h PBG) glycated hemoglobin (HbAlc) changes in the incidence of hypoglycemia and gastrointestinal tract. Results After treatment， patients FBG， 2 h PBG HbAlc were significantly decreased in both groups after which treatment FBG， HbAlc level difference was not statistically significant(P> 0.05)， two groups of patients 2 h PBG level and the difference was statistically significant(P <0.05 )； the study group and the control group， the incidence of hypoglycemia were 3 cases (6.0%) and 10 patients (20.0%)， the difference was statistically significant (P <0.05). Conclusion Insulin Glargine combined acarbose can better glucose control in type 2 diabetes， and the incidence of hypoglycemia in patients with low， worthy of clinical use.
[Key words] Insulin insulin； Acarbose； Type 2 diabetes mellitus
2型糖尿病(type 2 diabetes melitus，T2DM)是一种以长期高血糖为特征进行性代谢紊乱疾病，近年来随着人民生活水平的提高在我国发病率呈逐年上升趋势，长期高血糖可引起血管及神经病变，导致严重的大血管，微血管并发症的发生[1]。该院自2012年10月—2013年12月采用采用甘精胰岛素联合阿卡波糖对100例T2DM患者进行了治疗，取得了较好的效果，现报道如下。
1 材料与方法
1.1 一般资料
方便选择在该院门诊及住院T2DM患者100例，其中，所有患者均符合WHO1999年2型糖尿病诊断标准。排除标准：①严重的心脏疾患及肝肾功能异常；②合并泌尿系、呼吸道等严重感染；③妊娠、哺乳妇女；④继发糖尿病；⑤曾服用过可能影响血糖的药物(如糖皮质激素等)的病患者[2]。所有患者随机分为研究组及对照组，每组各50例，其中研究组男29例，女21例，患者年龄35～76岁，平均(49.8±7.4)岁。病程4～8年，平均(5.9±1.6)年；对照组男31例，女19例，患者年龄34～79岁，平均(46.1±5.6)岁。病程3～7年，平均(5.2±1.4)年。两组间性别，年龄，病程等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。 (陈穗琛 钱万桥)