急性缺血性卒中颈动脉粥样硬化斑块稳定性与血清Hepcidin—25水平的关系(1)
DOI：10.16662/j.cnki.1674-0742.2017.20.028
[摘要] 目的 探讨AIS患者不同时期、不同性质颈动脉斑块与血清铁调素25(Hepcidin-25)的关系。方法 方便选取2016年3—12月包医一附院神经内科筛选患者，将急性脑梗死组分为VP组(n=43)、SP组(n=45)、NP组(n=50)，选取同期正常体检人员50名为对照组。检测患者入院24 h，7 d，14 d的血清Hepcidin-25指标，入院时生化指标，对照组检测Hepcidin-25。结果 急性缺血性卒中患者入院时(50.18±8.46)μg/L、24 h(55.61±7.34)μg/L、7 d(63.43±9.16)μg/L、14 d (43.15±7.20)μg/L Hepcidin-25水平高于对照组，各个时期VP组高于SP组，SP组高于NP平组，差异有统计学意义(P<0.05)。结论 血清Hepcidin-25水平可作为诊断预测AIS指标。
[关键词] 急性缺血性卒中；颈动脉粥样硬化；斑块稳定性；血清Hepcidin-25
[中图分类号] R445 [文献标识码] A [文章编号] 1674-0742(2017)07(b)-0028-03
Correlation between the Stability of Carotid Atherosclerotic Plaque and Serum Hepcidin-25 Level of Acute Ischemic Stroke
NING Ke1， LIU Bo2
1.Clinical Medical Major， Graduate School of Baotou Medical College， Baotou， Inner Mongolia， 014040 China；2.Department of Neurology， First Affiliated Hospital of Baotou Medical College， Baotou， Inner Mongolia， 014010 China
[Abstract] Objective To discuss the correlation between the different periods and different natures of carotid atherosclerotic plaque and serum Hepcidin-25 level. Methods The patients with acute ischemic stroke in our hospital from March to December 2016 were convenient selected and divided into the VP group (n=43)， SP group (n=45)and NP group (n=50)， and 50 cases of normal physical examination staff at the same period were selected as the control group， and the serum Hepcidin-25 indexes at 24 h，7 d，14 d after admission and biochemical indexes at admission were tested and the Hepcidin-25 in the control group was tested. Results The serum Hepcidin-25 levels of patients with acute ischemic stroke at admission， 24 h， 7 d and 14 d after admission were respectively (50.18±8.46)μg/L， (55.61±7.34)μg/L， (63.43±9.16)μg/L， (43.15±7.20)μg/L， which were higher than those in the control group， and VP values in various stages were higher than that in the SP group， and in the SP group was higher than that in the NP group， and the difference was statistically significant(P<0.05). Conclusion The serum Hepcidin-25 level can be used as an index of diagnosis and prediction of AIS.
[Key words] Acute ischemic stroke； Carotid atherosclerotic plaque； Stability of plaque； Serum Hepcidin-25
急性缺血性卒中(Acute Ischemic Stroke，AIS)是臨床常见的脑血管病，我国老年人口比重逐年上升，进入未富先老情况，AIS发病率呈快速上升趋势[1]。AIS具有高致残、致死率，已成为居民主要卫生负担，如何有效的防治AIS成为临床研究热点[2]。方便选取140例患者于2016年3—12月在包医一附院神经内科就诊的，该研究通过探讨AIS患者不同时期、不同性质颈动脉斑块与血清Hepcidin-25的关系，为缺血性卒中的预防及早期治疗开辟了新途径，具有重要的临床意义，现报道如下。, http://www.100md.com(宁可 刘波)
[摘要] 目的 探讨AIS患者不同时期、不同性质颈动脉斑块与血清铁调素25(Hepcidin-25)的关系。方法 方便选取2016年3—12月包医一附院神经内科筛选患者，将急性脑梗死组分为VP组(n=43)、SP组(n=45)、NP组(n=50)，选取同期正常体检人员50名为对照组。检测患者入院24 h，7 d，14 d的血清Hepcidin-25指标，入院时生化指标，对照组检测Hepcidin-25。结果 急性缺血性卒中患者入院时(50.18±8.46)μg/L、24 h(55.61±7.34)μg/L、7 d(63.43±9.16)μg/L、14 d (43.15±7.20)μg/L Hepcidin-25水平高于对照组，各个时期VP组高于SP组，SP组高于NP平组，差异有统计学意义(P<0.05)。结论 血清Hepcidin-25水平可作为诊断预测AIS指标。
[关键词] 急性缺血性卒中；颈动脉粥样硬化；斑块稳定性；血清Hepcidin-25
[中图分类号] R445 [文献标识码] A [文章编号] 1674-0742(2017)07(b)-0028-03
Correlation between the Stability of Carotid Atherosclerotic Plaque and Serum Hepcidin-25 Level of Acute Ischemic Stroke
NING Ke1， LIU Bo2
1.Clinical Medical Major， Graduate School of Baotou Medical College， Baotou， Inner Mongolia， 014040 China；2.Department of Neurology， First Affiliated Hospital of Baotou Medical College， Baotou， Inner Mongolia， 014010 China
[Abstract] Objective To discuss the correlation between the different periods and different natures of carotid atherosclerotic plaque and serum Hepcidin-25 level. Methods The patients with acute ischemic stroke in our hospital from March to December 2016 were convenient selected and divided into the VP group (n=43)， SP group (n=45)and NP group (n=50)， and 50 cases of normal physical examination staff at the same period were selected as the control group， and the serum Hepcidin-25 indexes at 24 h，7 d，14 d after admission and biochemical indexes at admission were tested and the Hepcidin-25 in the control group was tested. Results The serum Hepcidin-25 levels of patients with acute ischemic stroke at admission， 24 h， 7 d and 14 d after admission were respectively (50.18±8.46)μg/L， (55.61±7.34)μg/L， (63.43±9.16)μg/L， (43.15±7.20)μg/L， which were higher than those in the control group， and VP values in various stages were higher than that in the SP group， and in the SP group was higher than that in the NP group， and the difference was statistically significant(P<0.05). Conclusion The serum Hepcidin-25 level can be used as an index of diagnosis and prediction of AIS.
[Key words] Acute ischemic stroke； Carotid atherosclerotic plaque； Stability of plaque； Serum Hepcidin-25
急性缺血性卒中(Acute Ischemic Stroke，AIS)是臨床常见的脑血管病，我国老年人口比重逐年上升，进入未富先老情况，AIS发病率呈快速上升趋势[1]。AIS具有高致残、致死率，已成为居民主要卫生负担，如何有效的防治AIS成为临床研究热点[2]。方便选取140例患者于2016年3—12月在包医一附院神经内科就诊的，该研究通过探讨AIS患者不同时期、不同性质颈动脉斑块与血清Hepcidin-25的关系，为缺血性卒中的预防及早期治疗开辟了新途径，具有重要的临床意义，现报道如下。, http://www.100md.com(宁可 刘波)