202例急性脑梗死患者血清同型半胱氨酸与叶酸检验结果相关分析(1)
[摘要] 目的 分析急性脑梗死患者血清同型半胱氨酸(Hcy)与叶酸检验结果的相关性。方法 随机选取该院2016年7月—2017年12月收治202例急性脑梗死患者作为急性脑梗死组，选取同期接收的202名体检健康者作为健康组，将全自动生化分析仪作为检验仪器，对研究对象的Hcy水平和叶酸水平进行检验。 结果 健康组的血清同型半胱氨酸(Acy)为(8.42±2.41)nmol/L，叶酸为(12.78±3.56)μg/L，急性脑梗死组患者的Hcy为(20.31±4.56)nmol/L，叶酸为(4.97±3.64)μg/L。两组比较，差异有统计学意义(t=4.056，4.237，P<0.05)。 结论 叶酸和Hcy是急性脑梗死的主要危险因素。因此，医务人员一旦发现患者出现上述症状，应立即为患者补充叶酸，合理控制患者的血清同型半胱氨酸水平，实现对急性脑梗死的有效预防。
[关键词] 急性脑梗死；血清同型半胱氨酸；叶酸
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)07(b)-0179-03
Analysis of Serum Homocysteine and Folic Acid in 202 Patients with Acute Cerebral Infarction
SHI Mei-xin1， ZHANG Bing1， LIANG Feng2
1.Department of Clinical Laboratory， Third People's Hospital of Qidong， Qidong， Jiangsu Province， 226200 China； 2.Qidong Third People's Hospital of Jiangsu Province， Qidong， Jiangsu Province， 226200 China
[Abstract] Objective To analyze the correlation between serum homocysteine (Hcy) and folic acid in patients with acute cerebral infarction. Methods A total of 202 patients with acute cerebral infarction who were admitted to the hospital from July 2016 to December 2017 were randomly selected as the acute cerebral infarction group. 202 healthy physical patients who were received during the same period were selected as the healthy group. The automatic biochemical analyzer was used as an inspection instrument. The test subjects' Hcy levels and folic acid levels were examined. Results The Hcy in the healthy group was (8.42±2.41) nmol/L， the folic acid was (12.78±3.56) ug/L， the Hcy in the acute cerebral infarction group was (20.31±4.56) nmol/L， and the folic acid was (4.97±3.64) ug/L. The difference between the two groups was statistically significant (t=4.056，4.237，P<0.05). Conclusion Folic acid and Hcy are the major risk factors for acute cerebral infarction. Therefore， once the medical personnel find out that the above-mentioned symptoms occur， they should immediately supplement the patient with folic acid and reasonably control the patient's serum homocysteine level to achieve effective prevention of acute cerebral infarction.
[Key words] Acute cerebral infarction； Serum homocysteine； Folic acid
現阶段，急性脑梗死患者人数在我国的发病率呈现逐年升高的发展趋势，仅仅依靠探索急性脑梗死的危险因素，不足以实现对疾病的有效预防，还需要探索其他的特异性因素。临床医学研究学者提出设想：血清同型半胱氨酸、叶酸与脑梗塞的发生具有十分密切的关系[1]。基于此，该次研究随机选取该院2016年7月—2017年12月收治202例急性脑梗死患者，探索了分析急性脑梗死患者血清同型半胱氨酸(Hcy)与叶酸检验结果之间的关联性，现报道如下。
1 资料与方法
1.1 一般资料
随机选取该院收治202例急性脑梗死患者作为急性脑梗死组，其中，男性98例，女性104例，年龄：49～86岁，平均(73.64±1.37)岁。选取同期接收的202名体检健康者作为健康组，其中，男性100例，女性102例，年龄：50～87岁，平均(72.91±1.69)岁两组患者均为急性期，所有患者均自愿参与研究，且经过伦理委员的批准，两组患者的一般资料比较差异无统计学意义(P>0.05)。, 百拇医药(施美新 张兵 梁枫)
[关键词] 急性脑梗死；血清同型半胱氨酸；叶酸
[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)07(b)-0179-03
Analysis of Serum Homocysteine and Folic Acid in 202 Patients with Acute Cerebral Infarction
SHI Mei-xin1， ZHANG Bing1， LIANG Feng2
1.Department of Clinical Laboratory， Third People's Hospital of Qidong， Qidong， Jiangsu Province， 226200 China； 2.Qidong Third People's Hospital of Jiangsu Province， Qidong， Jiangsu Province， 226200 China
[Abstract] Objective To analyze the correlation between serum homocysteine (Hcy) and folic acid in patients with acute cerebral infarction. Methods A total of 202 patients with acute cerebral infarction who were admitted to the hospital from July 2016 to December 2017 were randomly selected as the acute cerebral infarction group. 202 healthy physical patients who were received during the same period were selected as the healthy group. The automatic biochemical analyzer was used as an inspection instrument. The test subjects' Hcy levels and folic acid levels were examined. Results The Hcy in the healthy group was (8.42±2.41) nmol/L， the folic acid was (12.78±3.56) ug/L， the Hcy in the acute cerebral infarction group was (20.31±4.56) nmol/L， and the folic acid was (4.97±3.64) ug/L. The difference between the two groups was statistically significant (t=4.056，4.237，P<0.05). Conclusion Folic acid and Hcy are the major risk factors for acute cerebral infarction. Therefore， once the medical personnel find out that the above-mentioned symptoms occur， they should immediately supplement the patient with folic acid and reasonably control the patient's serum homocysteine level to achieve effective prevention of acute cerebral infarction.
[Key words] Acute cerebral infarction； Serum homocysteine； Folic acid
現阶段，急性脑梗死患者人数在我国的发病率呈现逐年升高的发展趋势，仅仅依靠探索急性脑梗死的危险因素，不足以实现对疾病的有效预防，还需要探索其他的特异性因素。临床医学研究学者提出设想：血清同型半胱氨酸、叶酸与脑梗塞的发生具有十分密切的关系[1]。基于此，该次研究随机选取该院2016年7月—2017年12月收治202例急性脑梗死患者，探索了分析急性脑梗死患者血清同型半胱氨酸(Hcy)与叶酸检验结果之间的关联性，现报道如下。
1 资料与方法
1.1 一般资料
随机选取该院收治202例急性脑梗死患者作为急性脑梗死组，其中，男性98例，女性104例，年龄：49～86岁，平均(73.64±1.37)岁。选取同期接收的202名体检健康者作为健康组，其中，男性100例，女性102例，年龄：50～87岁，平均(72.91±1.69)岁两组患者均为急性期，所有患者均自愿参与研究，且经过伦理委员的批准，两组患者的一般资料比较差异无统计学意义(P>0.05)。, 百拇医药(施美新 张兵 梁枫)