八宝五胆药墨治疗银屑病的临床效果分析(1)
[摘要] 目的 分析八宝五胆药墨治疗银屑病的临床效果。 方法 方便选取2017年2月—2018年2月该医院皮肤科门诊收治银屑病患者，随机分组，对照组60例阿维A治疗，观察组联合八宝五胆药墨内服与外敷治疗，持续8周，评价疗效与安全性。 结果 观察组整体疗效优于对照组，愈显率高于对照组，观察组2个月加重率3.70%低于对照组20.00%，差异有统计学意义(t=6.889，P<0.05)。对照组不良反应发生率3.64%，观察组发生率12.73%，差异无统计学意义(χ2=1.936，P=0.165>0.05)。 结论 八宝五胆药墨治疗银屑病，可以增进疗效，不会增加不良反应发生风险。
[关键词] 银屑病；八宝五胆药墨；临床疗效
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)02(c)-0115-03
[Abstract] Objective To analyze the clinical effect of Babao Wudan medicine ink in the treatment of psoriasis. Methods From February 2017 to February 2018， patients with psoriasis admitted to the hospital dermatology clinic were convenient selection randomly divided into two groups. 60 patients in the control group were treated with Avi A. The observation group was treated with Babao Wudan medicine for oral administration and external application. After 8 weeks， the efficacy and safety were evaluated. Results The overall efficacy of the observation group was better than that of the control group. The cure rate was higher than that of the control group. The 2-month exacerbation rate of the observation group was 3.70% lower than that of the control group (20.00%). The difference was statistically significant (t=6.889， P<0.05). The incidence of adverse reactions in the control group was 3.64%， and the incidence in the observation group was 12.73%. The difference was not statistically significant (χ2=1.936， P=0.165>0.05). Conclusion Babao Wudan medicine ink can improve psoriasis and increase the risk of adverse reactions.
[Key words] Psoriasis； Babao Wudan medicine ink； Clinical efficacy
銀屑病是一种以慢性皮肤疾病，发生机制较复杂，与免疫紊乱、遗传等因素有关[1]。中国银屑病发生率约为0.1～0.5%，meta分析显示该病发生于受潮、感染、外伤、饮酒、精神紧张等因素有关，因生活环境、生活方式改变，免疫、内分泌系统疾病发生率上升，银屑病的整体发生率也呈上升趋势[2]。银屑病损伤皮肤，影响患者的形象，给患者带来较大的心理压力。中医并无银屑病病名，从临床表现来看，当属于“白疕”“白壳”等证范畴，认为该病与血热、血燥、血虚、血瘀有关，口服方剂是主要治疗方法。八宝五胆药墨是一种新型墨药，有关于八宝五胆药墨治疗银屑病的研究非常罕见，该文以2017年2月—2018年2月，医院皮肤科门诊收治银屑病患者120例入组，评价八宝五胆药墨疗效、安全性。
1 资料与方法
1.1 一般资料
方便选取该医院皮肤科门诊收治银屑病患者入组。纳入标准：①参照共识意见明确诊断为寻常型银屑病，西医参照《临床皮肤病学(第3版)》诊断；②18～65岁；③知情同意[3]。排除标准：①过敏体质；②哺乳期、妊娠期女性；③病情严重，需要全身应用糖皮质激素或其他系统治疗药物；④合并其他重大疾病，如恶性肿瘤；⑤其他类型的皮肤疾病；⑥皮损位置特殊，如外阴；⑦无法获得随访；⑧近3个月使用过免疫治疗药物；⑨近2周使用过物理治疗，3 d内局部应用外用药物；⑩参加其他科学研究。退出标准：①依从性差，采用其他计划外的治疗方法；②误漏诊；③新发其他重大疾病，如急性阑尾炎；④无法获得随访；⑤出现严重的不良反应；⑥其他原因住院治疗；⑦治疗期间进行手术、接种疫苗、食物过敏、酗酒。入选对象120例，每入选1名符合纳入排除标准的对象，便随机分组。对照组60例，其中男37例、女23例，年龄(41.2±11.5)岁。症状表现：瘙痒55例，咽干口渴31例，心烦易怒22例，大便干燥、小便赤黄18例。皮损积分(PASI)(11.54±2.51)分。观察组60例，其中男35例、女25例，年龄(42.46±10.61)岁。症状表现：瘙痒54例，咽干口渴32例，心烦易怒21例，大便干燥、小便赤黄16例。皮损积分(PASI)(11.0±3.1)分。两组对象年龄、性别、症状表现、症状表现、皮损积分差异无统计学意义(P>0.05)。, 百拇医药(周文明)
[关键词] 银屑病；八宝五胆药墨；临床疗效
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2019)02(c)-0115-03
[Abstract] Objective To analyze the clinical effect of Babao Wudan medicine ink in the treatment of psoriasis. Methods From February 2017 to February 2018， patients with psoriasis admitted to the hospital dermatology clinic were convenient selection randomly divided into two groups. 60 patients in the control group were treated with Avi A. The observation group was treated with Babao Wudan medicine for oral administration and external application. After 8 weeks， the efficacy and safety were evaluated. Results The overall efficacy of the observation group was better than that of the control group. The cure rate was higher than that of the control group. The 2-month exacerbation rate of the observation group was 3.70% lower than that of the control group (20.00%). The difference was statistically significant (t=6.889， P<0.05). The incidence of adverse reactions in the control group was 3.64%， and the incidence in the observation group was 12.73%. The difference was not statistically significant (χ2=1.936， P=0.165>0.05). Conclusion Babao Wudan medicine ink can improve psoriasis and increase the risk of adverse reactions.
[Key words] Psoriasis； Babao Wudan medicine ink； Clinical efficacy
銀屑病是一种以慢性皮肤疾病，发生机制较复杂，与免疫紊乱、遗传等因素有关[1]。中国银屑病发生率约为0.1～0.5%，meta分析显示该病发生于受潮、感染、外伤、饮酒、精神紧张等因素有关，因生活环境、生活方式改变，免疫、内分泌系统疾病发生率上升，银屑病的整体发生率也呈上升趋势[2]。银屑病损伤皮肤，影响患者的形象，给患者带来较大的心理压力。中医并无银屑病病名，从临床表现来看，当属于“白疕”“白壳”等证范畴，认为该病与血热、血燥、血虚、血瘀有关，口服方剂是主要治疗方法。八宝五胆药墨是一种新型墨药，有关于八宝五胆药墨治疗银屑病的研究非常罕见，该文以2017年2月—2018年2月，医院皮肤科门诊收治银屑病患者120例入组，评价八宝五胆药墨疗效、安全性。
1 资料与方法
1.1 一般资料
方便选取该医院皮肤科门诊收治银屑病患者入组。纳入标准：①参照共识意见明确诊断为寻常型银屑病，西医参照《临床皮肤病学(第3版)》诊断；②18～65岁；③知情同意[3]。排除标准：①过敏体质；②哺乳期、妊娠期女性；③病情严重，需要全身应用糖皮质激素或其他系统治疗药物；④合并其他重大疾病，如恶性肿瘤；⑤其他类型的皮肤疾病；⑥皮损位置特殊，如外阴；⑦无法获得随访；⑧近3个月使用过免疫治疗药物；⑨近2周使用过物理治疗，3 d内局部应用外用药物；⑩参加其他科学研究。退出标准：①依从性差，采用其他计划外的治疗方法；②误漏诊；③新发其他重大疾病，如急性阑尾炎；④无法获得随访；⑤出现严重的不良反应；⑥其他原因住院治疗；⑦治疗期间进行手术、接种疫苗、食物过敏、酗酒。入选对象120例，每入选1名符合纳入排除标准的对象，便随机分组。对照组60例，其中男37例、女23例，年龄(41.2±11.5)岁。症状表现：瘙痒55例，咽干口渴31例，心烦易怒22例，大便干燥、小便赤黄18例。皮损积分(PASI)(11.54±2.51)分。观察组60例，其中男35例、女25例，年龄(42.46±10.61)岁。症状表现：瘙痒54例，咽干口渴32例，心烦易怒21例，大便干燥、小便赤黄16例。皮损积分(PASI)(11.0±3.1)分。两组对象年龄、性别、症状表现、症状表现、皮损积分差异无统计学意义(P>0.05)。, 百拇医药(周文明)