不同亚型抗环瓜氨酸肽抗体对类风湿关节炎诊断价值的比较研究(1)
[摘要] 目的 分析類风湿关节炎患者血清中不同亚型抗环瓜氨酸肽抗体的临床诊断价值。方法方便选取2016年7月—2018年6月期间该院收入的137例类风湿关节炎患者即为实验组1，选取同期收入的100例其他结缔组织病患者、100名健康体检者作为实验组2和对照组，均开展不同亚型的抗环瓜氨酸肽(CCP)抗体检查，比较类风湿因子(RF)-IgM 以及不同亚型的抗环瓜氨酸肽(CCP)抗体水平。 结果 实验组1受检人员抗CCP抗体IgG、抗CCP抗体IgA、抗CCP抗体IgM、RF-IgM(71.53%、56.20%、29.19%、74.45%)与实验组2(2.00%、2.00%、6.00%、19.00%)和对照组(1.00%、1.00%、1.00%、2.00%)对比，差异有统计学意义(χ2=114.585 2、118.232 7、76.428 2、79.785 6、19.885 9、32.124 6、71.132 6、137.431 6，P<0.05)。RF-IgM阴性类风湿关节炎患者(10.00%、26.67%、13.33%)对比RF-IgM阳性(89.71%、66.35%、35.51%)，差异有统计学意义(χ2=74.291 2、15.118 2、5.422 5，P<0.05)。≤6个月病程类风湿关节炎患者抗CCP抗体IgG、抗CCP抗体IgA、抗CCP抗体IgM(51.85%、29.62%、51.85%)与7～23个月(75.00%、60.41%、27.08%)、超过24个月(80.64%、65.62%、25.80%)对比，差异有统计学意义(χ2=4.166 7、7.719 8、6.552 6、11.097 9、4.601 1、5.710 0，P<0.05)。 结论 类风湿关节炎患者血清中抗 CCP抗体存在不同亚型，有利于早期诊断类风湿关节炎疾病。
[关键词] 类风湿关节炎;血清中抗环瓜氨酸肽抗体;不同亚型
[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-0742(2019)08(b)-0124-03
[Abstract] Objective To analyze the clinical diagnostic value of different subtypes of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. Methods Convenient select 137 patients with rheumatoid arthritis who were admitted from July 2016 to June 2018 were the experimental group 1. 100 patients with other connective tissue diseases and 100 healthy subjects were selected as the experimental group 2 and the control group， different subtypes of anti-cyclic citrullinated peptide(CCP) antibody test， comparing rheumatoid factor (RF)-IgM and different subtypes of anti-cyclic citrullinated peptide(CCP) antibody levels. Results The experimental group 1 was anti-CCP antibody IgG， anti-CCP antibody IgA， anti-CCP antibody IgM， RF-IgM (71.53%， 56.20%， 29.19%， 74.45%) and experimental group 2 (2.00%， 2.00%， 6.00%， 19.00%) and the control group (1.00%， 1.00%， 1.00%， 2.00%)， the difference was statistically significant (χ2=114.585 2， 118.232 7， 76.428 2， 79.785 6， 19.885 9， 32.124 6， 71.132 6， 137.431 6， P<0.05). RF-IgM negative rheumatoid arthritis patients (10.00%， 26.67%， 13.33%) were positive for RF-IgM (89.71%， 66.35%， 35.51%)， and the difference was statistically significant (χ2=74.291 2， 15.118 2， 5.422 5， P<0.05). Anti-CCP antibody IgG， anti-CCP antibody IgA， anti-CCP antibody IgM (51.85%， 29.62%， 51.85%) and 7 to 23 months (75.00%， 60.41%， 27.08%) in patients with rheumatoid arthritis of ≤6 months; for more than 24 months (80.64%， 65.62%， 25.80%)， the difference was statistically significant (χ2=4.166 7， 7.719 8， 6.552 6， 11.097 9， 4.601 1， 5.710 0， P<0.05). Conclusion There are different subtypes of anti-CCP antibodies in serum of patients with rheumatoid arthritis， which is helpful for early diagnosis of rheumatoid arthritis., http://www.100md.com(黄土艺)
[关键词] 类风湿关节炎;血清中抗环瓜氨酸肽抗体;不同亚型
[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-0742(2019)08(b)-0124-03
[Abstract] Objective To analyze the clinical diagnostic value of different subtypes of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. Methods Convenient select 137 patients with rheumatoid arthritis who were admitted from July 2016 to June 2018 were the experimental group 1. 100 patients with other connective tissue diseases and 100 healthy subjects were selected as the experimental group 2 and the control group， different subtypes of anti-cyclic citrullinated peptide(CCP) antibody test， comparing rheumatoid factor (RF)-IgM and different subtypes of anti-cyclic citrullinated peptide(CCP) antibody levels. Results The experimental group 1 was anti-CCP antibody IgG， anti-CCP antibody IgA， anti-CCP antibody IgM， RF-IgM (71.53%， 56.20%， 29.19%， 74.45%) and experimental group 2 (2.00%， 2.00%， 6.00%， 19.00%) and the control group (1.00%， 1.00%， 1.00%， 2.00%)， the difference was statistically significant (χ2=114.585 2， 118.232 7， 76.428 2， 79.785 6， 19.885 9， 32.124 6， 71.132 6， 137.431 6， P<0.05). RF-IgM negative rheumatoid arthritis patients (10.00%， 26.67%， 13.33%) were positive for RF-IgM (89.71%， 66.35%， 35.51%)， and the difference was statistically significant (χ2=74.291 2， 15.118 2， 5.422 5， P<0.05). Anti-CCP antibody IgG， anti-CCP antibody IgA， anti-CCP antibody IgM (51.85%， 29.62%， 51.85%) and 7 to 23 months (75.00%， 60.41%， 27.08%) in patients with rheumatoid arthritis of ≤6 months; for more than 24 months (80.64%， 65.62%， 25.80%)， the difference was statistically significant (χ2=4.166 7， 7.719 8， 6.552 6， 11.097 9， 4.601 1， 5.710 0， P<0.05). Conclusion There are different subtypes of anti-CCP antibodies in serum of patients with rheumatoid arthritis， which is helpful for early diagnosis of rheumatoid arthritis., http://www.100md.com(黄土艺)