耐碳青霉烯肠杆菌科细菌的临床分布特点及耐药性分析(1)
[摘要] 目的 分析耐碳青霉烯肠杆菌(CRE)的临床分布特点和耐药性，为指导临床用药和预防CRE感染提供科学依据。方法 收集2018年1月—2019年6月该院临床培养分离的CRE菌株82株，并进行药敏试验。观察CER菌株科室分布、性別分布、年龄分布、不同菌种以及对常用抗菌药物的耐药性。结果 CRE菌株的科室分布以ICU(35.4%)为主，其次为急诊科(20.7%)和神经外科(14.6%)，科室分布之间比较差异有统计学意义(χ2=138.761，P<0.05)。在82株CRE菌株中，男性54株(65.9%)，女性28株(34.1%)，差异有统计学意义(χ2=20.225，P<0.05)。15～60岁人群检出63株(76.8%)，高于0～14岁人群和>60岁人群，差异有统计学意义(χ2=130.254，P<0.05)。CRE菌株主要以肺炎克雷伯菌42株(51.2%)为主，其次为大肠埃希菌26株(31.7%)以及阴沟肠杆菌9株(10.9%)，病原菌分布之间比较差异有统计学意义(χ2=190.794，P<0.05)。CRE对大部分常用抗菌药物具有较高的耐药性，除了庆大霉素(57.3%)、妥布霉素(62.2%)、阿米卡星(39.0%)以外，其余均在70%以上。结论 CRE具有一定的临床分布特点，应当针对CRE检出较高的科室、人群采取有效的防控措施，根据CRE耐药性特点合理使用抗菌药物。
[关键词] 耐碳青霉烯肠杆菌;抗菌药物;耐药性;临床分布
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2020)06(a)-0190-03
Clinical Distribution Characteristics and Drug Resistance Analysis of Carbapenem-resistant Enterobacteriaceae
HAO Xiu-chun， HUANG Ting， YANG Hua， LIN Guan-shou， GU Guang-hong
Department of laboratory， Guangdong Zhongshan Torch Development Zone Hospital，Zhangshan，Guangdong Province，528437 China
[Abstract] Objective To analyze the clinical distribution characteristics and drug resistance of carbapenem-resistant Enterobacter (CRE)， and provide scientific basis for guiding clinical use and preventing CRE infection. Methods From January 2018 to June 2019， 82 strains of CRE strains isolated from clinical culture in the hospital were collected and tested for drug sensitivity. Observe the CER strain's departmental distribution， gender distribution， age distribution， different strains， and resistance to commonly used antibacterial drugs. Results The department distribution of CRE strains was mainly ICU (35.4%)， followed by emergency department (20.7%) and neurosurgery(14.6%). There was a statistically significant difference between the department distributions (χ2=138.761， P<0.05). Among 82 CRE strains， there were 54 males (65.9%) and 28 females (34.1%). The difference was statistically significant (χ2= 20.225， P<0.05). Sixty-three isolates (76.8%) were detected in the 15-60 year-old population， which was higher than that in the 0-14 year-old population and> 60-year-old population， and the difference was statistically significant(χ2=130.254， P<0.05). The CRE strains were mainly Klebsiella pneumoniae strains (51.2%)， followed by 26 strains of Escherichia coli (31.7%) and 9 strains of Enterobacter cloacae (10.9%). There were statistically significant differences in the distribution of pathogenic bacteria， with significance (χ2=190.794， P<0.05). CRE had a high resistance to most commonly used antibacterial drugs. Except for gentamicin (57.3%)， tobramycin (62.2%)， and amikacin(39.0%)，the rest are above 70%. Conclusion CRE has certain clinical distribution characteristics， and effective prevention and control measures should be taken for departments and populations with high CRE detection， and antibacterial drugs should be reasonably used according to the characteristics of CRE resistance., http://www.100md.com(郝秀春 黄婷 杨桦 林观寿 古广宏)
[关键词] 耐碳青霉烯肠杆菌;抗菌药物;耐药性;临床分布
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2020)06(a)-0190-03
Clinical Distribution Characteristics and Drug Resistance Analysis of Carbapenem-resistant Enterobacteriaceae
HAO Xiu-chun， HUANG Ting， YANG Hua， LIN Guan-shou， GU Guang-hong
Department of laboratory， Guangdong Zhongshan Torch Development Zone Hospital，Zhangshan，Guangdong Province，528437 China
[Abstract] Objective To analyze the clinical distribution characteristics and drug resistance of carbapenem-resistant Enterobacter (CRE)， and provide scientific basis for guiding clinical use and preventing CRE infection. Methods From January 2018 to June 2019， 82 strains of CRE strains isolated from clinical culture in the hospital were collected and tested for drug sensitivity. Observe the CER strain's departmental distribution， gender distribution， age distribution， different strains， and resistance to commonly used antibacterial drugs. Results The department distribution of CRE strains was mainly ICU (35.4%)， followed by emergency department (20.7%) and neurosurgery(14.6%). There was a statistically significant difference between the department distributions (χ2=138.761， P<0.05). Among 82 CRE strains， there were 54 males (65.9%) and 28 females (34.1%). The difference was statistically significant (χ2= 20.225， P<0.05). Sixty-three isolates (76.8%) were detected in the 15-60 year-old population， which was higher than that in the 0-14 year-old population and> 60-year-old population， and the difference was statistically significant(χ2=130.254， P<0.05). The CRE strains were mainly Klebsiella pneumoniae strains (51.2%)， followed by 26 strains of Escherichia coli (31.7%) and 9 strains of Enterobacter cloacae (10.9%). There were statistically significant differences in the distribution of pathogenic bacteria， with significance (χ2=190.794， P<0.05). CRE had a high resistance to most commonly used antibacterial drugs. Except for gentamicin (57.3%)， tobramycin (62.2%)， and amikacin(39.0%)，the rest are above 70%. Conclusion CRE has certain clinical distribution characteristics， and effective prevention and control measures should be taken for departments and populations with high CRE detection， and antibacterial drugs should be reasonably used according to the characteristics of CRE resistance., http://www.100md.com(郝秀春 黄婷 杨桦 林观寿 古广宏)