[摘要] 目的：制备艾塞那肽-乳酸/羟基乙酸共聚物(PLGA)微球，并研究PLGA分子量对微球性质的影响。方法：选用不同分子量的PLGA，采用复乳法制备艾塞那肽PLGA微球；对微球的粒径、载药量、包封率和体外释放等指标进行测定。结果：PLGA分子量对艾塞那肽PLGA微球的性质有明显影响。结论：可通过调节PLGA分子量调控微球的性质。

    [关键词] 艾塞那肽；微球；乳酸/羟基乙酸共聚物；分子量

    [中图分类号]R113[文献标识码]B [文章编号]1674-4721(2009)05(a)-117-02

    Effect of molecular weight of poly(Lactic-co-Glycolide) on properties of exenatide-loaded microspheres

    SHI Lin1, LIU Bin1, 2, WANG Mengshu1, WANG Chunyu3, KONG Wei1, CHEN Yan1*

    (1.College of Life Science, Jilin University, Changchun 130012, China；2.State Key Laboratory of Supramolecular Structure & Materials, Jilin University, Changchun 130012, China；3.Changchun Institute of Biological Products, Changchun 130062, China) ......