ILK\ER在子宫内膜癌组织中的表达及相关性分析(1)
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2010年3月25日
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[摘要] 目的:探讨整合素连接激酶(ILK)、雌激素受体(ER)在子宫内膜癌组织中的表达及相关性。方法:应用免疫组化SP法,检测60例子宫内膜癌、34例癌旁组织和20例正常子宫内膜标本中ILK、ER蛋白的表达情况。结果:①ILK蛋白在子宫内膜癌组织的阳性表达率为65.0%,显著高于正常内膜组织(5.0%)及癌旁组织(8.8%)(P<0.001)。②ER在正常子宫内膜及癌旁组织中的阳性表达率分别为100.0%、94.1%,均高于其在子宫内膜癌组织中的表达(50.0%)(P<0.001)。③ILK随着晚临床分期、组织低分化、深肌层浸润及发生淋巴结转移表达增高(P<0.05),ER表达与组织学分级、肌层浸润程度有关(P<0.05)。④ILK与ER在子宫内膜癌组织中的表达呈负相关(r=0.314,P=0.014)。结论:ILK在子宫内膜癌的发生、发展过程中发挥着重要作用,ER随细胞恶变而发生改变。对ILK、ER表达水平的联合检测在子宫内膜癌的诊断、治疗及判断预后方面有一定的指导意义。
[关键词] 子宫内膜癌;免疫组化;整合素连接激酶(ILK);雌激素受体(ER)
[中图分类号] R737.33 [文献标识码]A [文章编号]1674-4721(2010)03(c)-039-03
The study of expression and correlation of ilk and estrogenreceptor(er) in endometrial carcinoma
LI Chunling1,LIU Chunzai2,LI Shengshui3*,JIANG Ze4,XU Hua3,ZHANG Fengmei3,LIU Yan3,LI Shuangbiao3
(1.Department of gynecologic, Women and Children′s healthcare Hospital of Cangzhou,Cangzhou 061001, China;2.Department of pathology, Nandagang Hospital, Cangzhou 061103, China;3.Department of pathology, Integrated Chinese and Western Medicine Hospital of Cangzhou, Cangzhou 061001, China;4.Surgery department of Cangzhou Central Hospital,Cangzhou 061001, China)
[Abstract] Objective: To study the expression of ILK and estrogenreceptor(ER) in Endometrial carcinomas(EC),and to evaluate itscorrelation with the clinicopathological features. Methods: Tissues from 60 EC,34 paracarcinoma and 20 norma1endometrium were analyzed for ILK and ER expression by immunohistochemical SP method. Results: The expression of ILK in EC, paracarcinoma and normal endometrium were 65.0%,8.8% and 5.0% respectively. The expression of ILK was significantly higher in EC than that in paracarcinoma and normal endometrium(P<0.001).The expression of ER in normal endomtrium and parac arcinoma was 100.0%,94.0%,which was significantly higher than that in EC(50.0%,P<0.001).ILK expression was associated with clinical stage,histological grade,myometrial invasion and lymph node metastasis(P<0.05).ER expression was associated with histologic grade and myometrial invasion(P<0 ......
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