男性急性冠脉综合征血清睾酮与AngⅡ水平相关性研究(1)
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2010年4月15日
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[摘要] 目的:观察不同类型男性冠心病患者血清睾酮、游离睾酮与血管紧张素-Ⅱ(angiotensin Ⅱ, AngⅡ)水平改变及相互间关系,进一步探讨睾酮与AngⅡ在男性急性冠脉综合征(acute coronary syndrome,ACS)发病中的作用。方法:冠心病(coronary heart disease,CHD)患者分为急性心肌梗死(acute myocardial infarction,AMI)组、不稳定型心绞痛(unstable angina pectoris,UAP)组、稳定型心绞痛(stable angina pectoris,SAP)组,每组30例患者,另设健康对照组30例,比较各组间血清睾酮、游离睾酮与AngⅡ水平差异并分析其相关性。结果:AMI组和UAP组血清游离睾酮与AngⅡ水平与对照组比较,差异有统计学意义(P<0.01),ACS患者血清游离睾酮与AngⅡ水平之间呈负相关(P<0.01)。结论:血清游离睾酮与AngⅡ水平改变与ACS的发生有关,它们可作为评价冠状动脉粥样硬化斑块稳定性与病变严重程度的一个参考指标,并为临床预防和治疗ACS开辟了新的途径。
[关键词] 急性冠脉综合征;睾酮;游离睾酮;血管紧张素-Ⅱ
[中图分类号] R 542.22 [文献标识码]A [文章编号]1674-4721(2010)04(b)-011-03
Research about correlation between the serum levels of testosterone and AngⅡ in the male patients with ACS
YUE Chuanzhe1,LIU Shuang2,CHEN Guiying3*
(1.The Second Outpatient Department in Herbalist-Mongolian Medicine Hospital of Hulunbuer City,Hulunbuer 021008,China;2.Geriatric Department of People′s Hospital of Hulunbuer,Hulunbuer 021008,China;3.Department of Cardiology,the First Clinic Medical College of harbin Medical University,Harbin 150001,China)
[Abstract] Objective: To evaluate the peripheral levels of testosterone,free testosterone, AngⅡ,and association between them in patients with different type of coronary heart disease,further more to understand the role testosterone and AngⅡ played in the pathogenesis of male with ACS.Methods:For measuring serum concentrations of testosterone, free testosterone,and AngⅡ,three groups of 30 patients with acute myocardial infarction(AMI),unstable angina pectoris(UAP),and SAP and one equivalent group of 30 healthy volunteers(control group) were recruited.The serum levels of testosterone and free testosterone were measured with ELISA method,of AngⅡ were measure with radioimmunity method.Results:The serum level of free testosterone in the patients with ACS was significantly lower,but AngⅡ was not ably higher than those in the control group(P<0.01).Significant negative correlation between the serum levels of free testosterone and AngⅡ was observed in the patients with ACS (P<0 ......
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