东莨菪碱在治疗重型创伤性脑损伤中的临床疗效观察
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2010年11月5日
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[摘要] 目的：观察东莨菪碱治疗重型创伤性脑损伤的临床疗效，探讨提高重型创伤性脑损伤临床疗效的治疗方法。方法：选择确诊为重型创伤性脑损伤患者87例，随机分为对照组与观察组，对照组42例采用常规外科治疗，观察组45例在常规外科治疗的基础上加用东莨菪碱治疗，比较两组患者治疗后动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)及术后6个月的临床疗效。结果：观察组临床疗效好于对照组，在治疗后动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)及术后6个月的临床疗效方面比较，差异有统计学意义(P<0.05) 。结论：对重型创伤性脑损伤患者加用东莨菪碱治疗，可明显提高临床治疗效果，值得临床广泛推广。
[关键词] 东莨菪碱；重型；颅脑损伤
[中图分类号] R651.1+5 [文献标识码]B [文章编号]1674-4721(2010)11(a)-047-02
Clinical effects observation of scopolamine in treatment of severe traumatic brain injury
MA Banyou, ZHOU Jiye, WANG Shouhai, GE Yongxing, HE Guizhi, YIN Xiaohong,(Department of Neurosurgery, Changzhou Tumor Hospital Affiliated to Medical School of Soochow University, Jiangsu Province, Changzhou 213001, China)
[Abstract] Objective: To observe the clinical effects of Scopolamine in treatment of severe traumatic brain injury. Methods: Collected 87 patients with severe traumatic brain injury, they were randomly divided into control group and observer group,42 patients were divided into control group with general surgery treatment,45 patients were divided into observer group with general surgery and Scopolamine treatment, then compare PaO2, PaO2/FiO2 and the clinical effect after 6 months. Results: The observer group′s clinical effects was better than the control group′s,there was a statistical significance(P<0.05) in PaO2, PaO2/FiO2 and the clinical effect after 6 months. Conclusion: Patients with severe traumatic brain injury are treated with scopolamine； it can increase the clinical effects obviously and should be widely promoted.
[Key words] Scopolamine； Severe； Head injury
创伤性脑损伤(traumatic brain injury ，TBI)是神经外科最常见的疾病，重型创伤性脑损伤的死亡率及致残率极高。重型创伤性颅脑损伤，占急性颅脑损伤的13%~21%，自CT、MRI应用以来其诊断有了明显的提高 ......
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