首次脑卒中后抑郁临床研究(1)
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[摘要] 目的：探讨首次脑卒中后抑郁(post-stroke depression，PSD)的发生率及其危险因素，为卒中后抑郁的干预及方法提供依据。方法：连续入组的发病72 h内入院的急性脑卒中患者127例，根据入院14 d内汉密尔顿抑郁量表(17项)评分分为PSD组和非PSD组，分析并比较PSD与性别、婚姻状况、年龄、文化程度、卒中类型、病灶部位、高血压、糖尿病、冠心病、吸烟、饮酒、体质量指数(BMI)、卒中家族史、颈动脉斑块、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)和简易精神状态检查(MMSE)量表评分等临床因素的关系。结果：本组PSD发生率为36.2%(46例)。PSD组男性、脑梗死比率、伴高血压病比率、伴糖尿病比率及伴冠心病比率、入院时BI明显低于非PSD组(P<0.05或0.01)。结论：脑卒中急性期患者PSD的发生率较高，男性、脑梗死、合并高血压、糖尿病、冠心病和入院时BI是PSD的独立危险因素。
[关键词] 卒中后抑郁；发生率；危险因素；干预
[中图分类号] R749.4 [文献标识码]A[文章编号]1674-4721(2011)04(a)-042-02
Clinical study on post-stroke depression
SONG Mei, YU Min
Department of Neurology, Second Ward, the ThirdPeople's Hospital of Dalian City, Liaoning Province, Dalian 116031,China
[Abstract] Objective: To investigate the incidence and its risk factors of post-stroke depression (PSD) in cerebral stroke patients at acute stage. Methods: 127 stroke patients consecutive admitted to hospital within 72 h onset were divided into PSD group and non-PSD group according to the scores of 17-item Hamilton Depression Rating scale (HAMD) in the 14 d after admission. The relationship between PSD and clinical factors including sex, marital status, age, education, stroke type, lesionlocation, hypertension, diabetes, coronaryarterydisease, smoking, drinking, BMI, family history of stroke, score of National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), and score of mini mental statue examination (MMSE) were analyzed. Results: The PSD incidence in this group was 36.2%(46 cases). In PSD group, man were easier to hypertension, the infarct volume and scores of BI on admission were significantly higher, BI and score of MMSE on admission were significantly lower than non-PSD group (P<0.05 or 0.01). Conclusion: The incidence of PSD in patients with cerebal stroke at acute stage is high. The cerebral infarction, hypertension and BI on admission are the independent risk factors of PSD.
[Key words] Post-stroke depression; Incidence; Risk factor; Intervention
随着卒中发病率的居高不下，急性脑卒中后抑郁亦逐渐被我们所认识。卒中后抑郁(PSD)是脑卒中常见并发症，增加病死率，降低患者的生活质量，严重影响患者的预后，并增添家庭社会的负担 ......
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