双环醇片防治肿瘤化疗药物性肝损害的研究(1)
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[摘要] 目的：评价双环醇片对肿瘤化疗药物所致肝损害的治疗和预防作用。方法：随机选取62例初次肿瘤化疗后出现药物性肝损害的患者，开始口服双环醇片 50 mg 每日3次。待肝功能恢复正常后再次按照原方案化疗时，继续口服双环醇片50 mg 每日3次，持续14 d，前后进行自身对照。观察口服双环醇片对肿瘤患者化疗后肝损害所致谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBiL)等肝功能的影响。同时，观察口服双环醇片治疗肿瘤化疗药物所致肝损害恢复正常后，化疗同时联合双环醇片预防性保肝治疗，比较该次与单纯化疗前后的ALT、AST、TBiL差值。结果：口服双环醇片治疗化疗后肝损害，肝功能ALT、AST等指标明显降低，在中位时间8.5 d恢复正常。在预防化疗所致肝损害上，化疗与双环醇片联合治疗前后的ALT、AST差值明显减小，与单纯化疗前后比较，差异有统计学意义(P<0.01)。结论：双环醇片可以有效治疗和预防化疗药物对肝脏的损害。
[关键词] 双环醇片；化疗；防治；药物性肝损害
[中图分类号] R730.53 [文献标识码]A [文章编号]1674-4721(2011)06(b)-005-02
Study of bicyclol in the prevention and treatment of hepatic damage caused by chemotherapy
ZENG Wucha, LIN Xuede, ZHANG Zhifeng, HUANG Yi, SHI Xi
Department of Chemotherapy, the First Affiliated Hospital of Fujian Medical University, Fujian Province, Fuzhou350005, China
[Abstract] Objective: To evaluate the efficacy of bicyclol in the prevention and treatment of hepatic damage caused by chemotherapeutic drugs. Methods: Sixty-twopatients with hepatic damage caused by chemotherapy were randomly chosen to receive bicyclol 50 mg tid orally after they were found hepatic damage caused by chemotherapeutic drugs. The influence of Bicyclol to ALT, AST, TBiL of cancer patients were observed after liver damage induced by Chemotherapy. After the recovery of the liver damage of these patients, the prophylactically protective effects of bicyclol to liver damage were also studied by combination cure of bicyclol and chemotherapy. Results: Bicyclol could obviously reduce the elevated ALT and AST level caused by chemotherapy. When used as a preventive medicine，combination cure of Bicyclol and Chemotherapy had protective effect to liver damage compared with Chemotherapy without Bicyclol(P<0.01). Conclusion: Bicyclol can effectively treat and protect the liver damage caused by Chemotherapy.
[Key words] Bicyclol; Chemotherapy; Prevention and cure; Hepatic damage
全身化疗是恶性肿瘤的一种常用的治疗手段。足量、按时用药是保证疗效的重要前提。但化疗药物常导致肝功能损害，以致化疗间歇期延长或停止化疗，影响疗效。双环醇片具有很好的保肝降酶作用。理论上，合理应用双环醇片能够改善化疗所致的肝功能损害并保证化疗的按期进行。笔者应用双环醇片治疗62例恶性肿瘤化疗药物所致肝损害患者，以进一步了解该药对抗肿瘤化疗药物所致肝损害的治疗及预防作用。
1资料与方法
1.1一般资料
选取2009年10月~2010年4月本科收治的62例化疗后出现药物性肝损害的恶性肿瘤患者 ......
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