那格列奈对2型糖尿病患者早时相胰岛B细胞功能影响的研究
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[摘要] 目的：探讨那格列奈对2型糖尿病患者早时相胰岛B细胞功能的影响。方法：选择2010年2月～2011年2月本院初诊为2型糖尿病患者36例，所有患者均给予那格列奈治疗，周期为2个月。比较治疗前及治疗2个月后患者血浆葡萄糖、胰岛素及血浆糖化血红蛋白水平。结果：①那格列奈治疗效果明显，患者口服糖耐量试验各时段血糖水平与治疗前比较均有较明显降低(P<0.05)。②治疗后，血浆糖化血红蛋白平均为(6.1±1.4)%，与治疗前相比差异有统计学意义(P<0.05)。③治疗后，口服糖耐量试验30、60 min胰岛素水平较治疗前明显升高(P<0.05)。治疗2个月后胰岛素分泌峰值出现在60 min，180 min时恢复到较低水平。结论：那格列奈能够有效降低2型糖尿病患者血糖，促进早时相胰岛素分泌。
[关键词] 2型糖尿病；那格列奈；胰岛素；胰岛B细胞
[中图分类号] R587.1 [文献标识码]A[文章编号]1674-4721(2011)07(a)-020-03
Impact study of nateglinide in the early phase of type B islet cell function in type 2 diabetic patients
TAN Donghong, HUANG Haizhen
Endocrinology Department in Central Hospital of Guangdong Province Agriculture Reclamation, Zhanjiang 524002, China
[Abstract] Objective: To investigate the effect of nateglinide in the early phase of type B islet cell function in type 2 diabetic patients. Methods: 36 cases type 2 diabetes patients who were treated in our hospital from February 2010 to February 2011 were chosen. All patients were treated with nateglinide for two months. The glucose levels, insulin levels and plasma glycated hemoglobin levels before after treatment were compared. Results: ①Compared with before, the glucose level of oral glucose tolerance test were much lower (P<0.05). ②After treatment, the mean plasma glycated hemoglobin levels were (6.1±1.4)%，compared with before, there were statistically differences (P<0.05). ③After treatment, the 30 min and 60 min insulin levels were higher than before (P<0.05). 2 months after treatment the insulin peak were in 60 minutes, In 180 minutes they returned to low level. Conclusion: Nateglinide can effectively reduce blood glucose in patients with type 2 diabetes, and promote early phase insulin secretion.
[Key words] Type 2 diabetes; Nateglinide; Insulin; Islet B cells
糖尿病是内分泌系统常见病和多发病，它能导致心血管、脑血管、肾脏、视网膜及外周神经多种并发症的发生，严重影响了患者的寿命及生活质量，其早期的诊断和治疗尤为重要。2型糖尿病(type 2 diabetes)的早期阶段，胰岛B细胞功能轻度异常而导致的餐后胰岛素第1时相分泌水平的降低是其主要的病理生理过程[1]。那格列奈(nateglinide)属于一种苯丙胺酸类衍生物，它能通过刺激胰岛B细胞的早期分泌，稳定胰岛素分泌曲线，快速增加餐后胰岛素水平，降低餐后血糖及空腹血糖[2]。本研究中，笔者对36例初诊的2型糖尿病患者应用那格列奈治疗，分析其临床疗效。
1 资料与方法
1.1 一般资料
选择2010年2月～2011年2月于本院内分泌科诊治的2型糖尿病患者36例 ......
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