血管紧张素受体拮抗剂在进展性肾炎大鼠模型中对慢性低氧引起肾小管间质损害的抑制作用(3)
 |
| 第1页 |
参见附件(4415KB，4页)。
[参考文献]
[1]Fine LG, Norman JT.Chronic hypoxia as a mechan ism of progression of chronic kidney diseases:from hypothesi s to novel therapeutics[J].Kidney Int,2008,74(7):867-872.
[2]Greijer AE,van der GP,Kemming D,et al.Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia inducible factor-1α (HIF-1α)[J].J Pathol, 2005,206(3):291-304.
[3]Takiyama Y,Harumi T,Watanabe J,et al.Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism[J].Diabetes,2011,60(3):981-992.
[4]Higgins DF,Bijiu MP.Hypoxic induction of TGF-β is directly mediated by Hif-1[J].Am J Physiol Renal Physiol,2004,287(6):F1223-F1229.
[5]Norman JT,Clark IM. Hypoxia promotes fibrogenesis in human renal fibroblasts[J].Kidney Int,2008,58(6):2351-2366.
[6]Matsumoto M.Hypoperfusion of peritubular capillaries induces chronic hypoxia before progression of tubulointerstitial injury in a progressive model of rat glomerulonephritis [J].J Am Soc Nephrol,2004,15(6):1574 -1581.
[7]Kimura K,Iwano M,Higgins DF,et al.Stable expression of H IF-1α in tubular epithelial cell promotes interstitial fibrosis[J].Am J Physiol Renal Physiol,2008,295(4):F1023-F1029.
[8]Manotham K, Tanaka T, Matsumoto M, et al. Evidence of tubular hypoxia in the early phase in the progressive nephritis model[J].Am Soc Nephrol,2004,15(5):1277-1288.
[9]Kong X,Zhang DY,Wu HB,et al.Losartan and pioglitazone ameliorate nephropathy in experimental metabolic syndrome rats [J].Biol Pharm Bull,2011,34(5):693-699.
[10]Meier P,Maillard MP.Combining blockers of the renin-angiotensin system or increasing the dose of an angiotensin[J].Hypertens,2011,29(6):1228-1235.
(收稿日期：2011-06-10)
您现在查看是摘要介绍页，详见PDF附件(4415KB，4页)。