米非司酮对乳腺癌细胞系MCF-7/ADM裸鼠移植瘤耐药逆转作用(1)
 |
| 第1页 |
参见附件(2787KB，3页)。
[摘要] 目的：探讨米非司酮对乳腺癌细胞系MCF-7/ADM裸鼠移植瘤耐药逆转作用。方法：以人乳腺癌细胞系MCF-7/ADM建立耐阿霉素人乳腺癌裸鼠皮下移植瘤动物模型，将成瘤裸鼠随机分为空白对照组，米非司酮组(MIF组)，阿霉素组(ADM组)，米非司酮联合阿霉素组(MIF+ADM组)。测量裸鼠移植瘤横径与短径，计算移植瘤体积，绘制生长曲线。结果：对裸鼠干预处理4周后，MIF+ADM组移植瘤体积[(232.514 9±309.237 7) mm3]最低，ADM组[(508.964 8±16.260 9) mm3]次之，均低于空白对照组移植瘤体积[(962.230 9±261.131 3) mm3]，差异有统计学意义(P<0.05)；MIF+ADM组移植瘤体积较单独用药的MIF组及ADM组低，差异具有统计学意义(P<0.05)。结论：米非司酮有逆转乳腺癌细胞MCF-7/ADM裸鼠移植瘤耐药性的作用。
[关键词] 乳腺癌；多药耐药；米非司酮；移植瘤
[中图分类号] R737.9 [文献标识码]A[文章编号]1674-4721(2011)08(a)-028-03
Reversal effect of mifepristone on MCF-7/ADM cell line in breast cancer xenograft of nude mice
HUANG Yuting1, Huang Junhui2, ZHU Ming3
1.Department of Radiotherapy Oncology, Huizhou Municipal Central Hospital, Guangdong Province, Huizhou 516001, China; 2.Department of Chemotherapy Oncology, Xiangya Hospital Central-south University, Hunan Province, Changsha 410008, China; 3.Department of Cardiothoracic Surgery, Huizhou Municipal Central Hospital, Guangdong Province, Huizhou 516001, China
[Abstract] Objective: To research the reversal effect of mifepristone on MCF-7/ADM cell line in breast cancer xenograft of nude mice. Methods: Established adriamycin resistance human breast cancer animal models that xenofraft transplanted subcutaneous in nude mice by adriamycin resistance cell line of human breast cancer MCF-7/ADM. The mice with xenofraft were divided into four groups randomly, control group，mifepristoneon group (MIF)，adriamycin group(ADM)，mifepristone+adriamycin group(MIF+ADM). Measured the xenografts′ long and short diameters，calculated the volumes of xenofrafts and drew the growth curve. Results: After the 4 weeks′ treatment, the xenograft volume of mifepristone+adriamycin group [(232.514 9±309.237 7) mm3] was the smllest, adriamycin group [(508.964 8±16.260 9) mm3] smaller, compared with control group[(962.230 9±261.131 3) mm3], with statistical significance (P<0.05). The xenograft volume of mifepristoneon+adriamycin group was smaller than mifepristone group and adriamycin group (P<0 ......
您现在查看是摘要介绍页，详见PDF附件(2787KB，3页)。