高血压合并2型糖尿病患者血浆脂联素与血管内皮功能相关性研究(1)
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[摘要] 目的：探讨高血压(EH)合并2型糖尿病(T2DM)患者血浆Adiponectin水平与血管内皮功能的关系。方法：选取研究对象105例根据标准分为正常对照组(NC组)、原发性高血压组(EH组)、高血压合并2型糖尿病组(EH+T2DM组)，各组分别测定脂联素(Adiponectin)、血栓调节蛋白(Tm)、一氧化氮(NO)，并进行对比及相关分析。结果：与NC组比较，EH+T2DM组和EH组Tm明显增高(P<0.05)，血浆Adiponectin 和NO明显降低(P<0.05)。与EH组比较，EH+T2DM组的 Tm 明显增高，血浆Adiponectin 和NO明显降低(P<0.05)。 EH+T2DM组血浆Adiponectin水平与Tm呈显著负相关(r=-0.353、P<0.05)；与NO呈显著正相关(r=0.279，P<0.05)；Tm与NO呈明显负相关(r=-0.319，P<0.05)。血浆Adiponectin和NO是平均动脉压独立的影响因素。结论：EH患者体内存在Adiponectin、 NO和Tm的异常表达，合并T2DM患者更为显著。血浆Adiponectin可能通过调节血管内皮功能进而在EH、EH合并T2DM的发病机制中具有重要作用，此为早期干预EH+T2DM提供了理论依据。
[关键词] 高血压；2型糖尿病；血栓调节蛋白；一氧化氮
[中图分类号] R544.1 [文献标识码]A [文章编号]1674-4721(2011)08(b)-013-03
Relationship between plasma adiponectinand vascular endothelial function in patients with essential hypertension and type 2 diabetes mellitus
WANG Zhenhua1, LONG Lijuan2, ZHAO Gang2, WANG Jianbo2
1.Department of Third Internal Medicine, People′s Hospital of Wushan County, Chongqing 404700, China;
2.Department of First Internal Medicine, People′s Hospital of Wushan County, Chongqing 404700, China
[Abstract] Objective: To investigate the relationship between plasma adiponectin levels and vascular endothelial function in patients with essential hypertension and type 2 diabetes mellitus. Methods: 32 subjects with normal control (NC), 35 patients with essential hypertension (EH) and 38 patients with EH complicated by T2DM (EH+T2DM) participated in this study. Fasting plasma adiponectin, thrombomodulin (Tm) and nitric oxide (NO) levels were measured by enzyme-linked immunosorbent assay (ELISA). Comparative and related analysis among them was also conducted. Results: Patients with EH and EH complicated by T2DM had significantly higher Tm(P<0.05) and lower plasma adiponectin and NO levels than that of NC group (P<0.05); Patients with EH complicated by T2DM had significantly higher Tm levels and lower plasma adiponectin and NO levels than that of EH group (P<0 ......
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