米非司酮配伍依沙吖啶与单纯依沙吖啶终止中期妊娠的效果比较(1)
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[摘要] 目的：探讨米非司酮配伍依沙吖啶与单纯依沙吖啶终止中期妊娠的临床效果。方法：总结本院2008年10月～2010年5月收治的65例妊娠16～24周患者的资料，将其随机分为观察组和对照组，观察组40例，口服米非司酮片50 mg，q12 h×2 d，第3天行依沙吖啶引产，对照组25例直接行依沙吖啶引产。结果：观察组平均引流产时间为(37.3±13.2) h，与对照组的(46.2±16.8) h比较，差异有统计学意义(P<0.05)，产后刮出物量也低于对照组(P<0.05)。结论：米非司酮配伍依沙吖啶终止中期妊娠临床效果好，适宜临床广泛推广。
[关键词] 米非司酮；依沙吖啶；中期妊娠；引产
[中图分类号] R979.2+2 [文献标识码] B [文章编号] 1674-4721(2011)11(c)-068-02
Comparison of mifepristone combined with ethacridine in induction of labor for the termination of second trimester pregnancy
LIU Shuqin1, CHEN Yuqin2
1.The People's Hospital of Lushan County, Henan Province, Lushan 467300, China; 2.Lushan Family Planning Service Station of Henan Province, Lushan 467300, China
[Abstract] Objective: To investigate the clinical efficacy of mifepristone combined with ethacridine in induction of labor for the termination of second trimester pregnancy. Methods: The 65 women at 16-24 weeks' gestation requesting termination of second-trimester pregnancy were randomized into observation group and control group, who were treated by the hospital from October 2008 to May 2010. The 40 women of the observation group were taken 50 mg mifepristone every 12 hours for two days and followed by the induced labor with ethacridine in the third day, while the 25 women of the control group were directly treated induced labor with ethacridine. Results: The time of induced labor in observation group was (37.3±13.2) h, which was significantly shorter than that (46.2±16.8) h in the control group (P<0.05), the amount of tissue scratched out from the uterus were significantly lower in the observation group than ones in the control group (P<0.05). Conclusion: Mifepristone combined with ethacridine in induction of labor is more effective than induced labor using ethacridine directly, and widely suitable for clinical applications.
[Key words] Mifepristone; Ethacridine; Mid-pregnancy; Abortion
近年来，随着生活环境及人们思想观念的转变，出现了越来越多的未婚少女及计划外怀孕而要求终止妊娠的妇女，由于她们缺乏相关的医学知识，错过了早期妊娠流产的时机，中期妊娠引产成了终止妊娠必要的途径。笔者在临床工作中采用米非司酮配伍依沙吖啶终止中期妊娠，效果满意，现报道如下：
1 资料与方法
1.1 一般资料
自2008年10月～2010年5月，本院收治妊娠16～24周孕妇65例，将其随机分为观察组40例，对照组25例，两组年龄、孕次、产次、孕周方面差异无统计学意义(P>0.05)。两组一般资料比较见表1。
1.2 方法
1.2.1 术前准备 详细询问病史，测量体温、脉搏、呼吸、血压，进行全身检查及妇科检查，排除生殖器官畸形、急性生殖器官炎症、肿瘤，血常规、尿常规、凝血功能及肝肾功能均正常，无米非司酮及依沙吖啶引产禁忌 ......
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