[摘要] 目的：研究骨髓增生异常综合征(MDS)转变post MDS-AL临床表现及联合化疗成效。方法：运用WHO标准开展成效回顾。结果：62例患者中12例转为急性白血病(AL)，主要属于AML，中位转白期限12个月，联合化疗总体有效率为(OR)67%。结论：MDS高危向AL转化，post MDS-AL治疗难度极大，预后成效不佳。

    [关键词] 骨髓增生异常综合征；急性白血病；联合化疗；预后

    [中图分类号] R552 [文献标识码] A [文章编号] 1674-4721(2011)12(b)-030-02

    Clinical analysis of myelodysplastic syndrome change to acute leukemia

    XIAO Licheng

    The Third People's Hospital of Xinghua City, Jiangsu Province, Xinghua 225700, China

    [Abstract] Objective: To study changes in post MDS-AL MDS clinical manifestations and the effectiveness of combination chemotherapy. Methods: WHO standard was used in effectiveness review. Results: In sixty-two cases of patients, 12 cases changed to AL, primarily AML, the median duration of 12 months to white, the overall response rate was combined with chemotherapy (OR) 67%. Conclusion: MDS high-risk conversion to the AL, post MDS-AL treatment is extremely difficult, the prognosis is poor performance. ......