原因不明习惯性流产患者自身抗体检测的临床意义(1)
 |
| 第1页 |
参见附件。
[摘要] 目的：通过对原因不明习惯性流产(HA)患者自身抗体的检测，探讨其自身抗体与发病的关系。方法：对106例原因不明的HA患者采用ELISA法检测血清抗心磷脂抗体(ACA)、抗子宫内膜抗体(EMAb)、抗精子抗体(ASAb)，间接免疫荧光法测定抗核抗体(ANA)，免疫印迹法检测可抽提核抗原抗体(ENA)和抗双链DNA抗体(ds-DNA)，斑点法检测抗平滑肌抗体(SMA)、抗线粒体抗体(AMA)。结果：原发性和继发性HA患者ACA、EMAb、AsA、ANA、SMA阳性率差异无统计学意义(P>0.05)，但与对照组相比差异有统计学意义(P<0.01)。原发性和继发性习惯性流产患者的URNP、ds-DNA、SSA、Sm、SSB、Jo-1、Scl-70差异无统计学意义。结论：原因不明性习惯性流产患者体内存在自身抗体，主要有ACA、EMAb、SMA、ANA等，自身抗体的存在是造成原因不明性习惯性流产的原因。
[关键词] 流产；习惯性；自身抗体；自身免疫
[中图分类号] R714.21 [文献标识码] A [文章编号] 1674-4721(2012)01(a)-012-03
The clinical significance of autoantibodies for unexplained habitual abortion patients
WANG Huanxin1, LIU Guoning1, MA jindong2
1.Fangzi District People' Hospital in Shandong Province, Weifang 261200, China; 2.Weifang People's Hospital in Shandong Province, Weifang 261041, China
[Abstract] Objective: To explore the relationship between autoantibodies and disease by unexplained habitual abortion (HA) in patients with autoantibodies. Methods: One hundred and six cases of unexplained HA detected by ELISA in patients with serum anti-cardiolipin antibodies (ACA), anti-endometrial antibodies (EMAb), anti-sperm antibodies (ASAb), Indirect immunofluorescence determination of anti-nuclear antibody (ANA), Western blot extractable nuclear antigen antibodies (ENA) and anti-double-stranded DNA antibodies (ds-DNA), anti-smooth muscle antibodies were detected spots (SMA), anti-mitochondrial antibody (AMA). Results: Positive rate of ACA, EMAb, ASAb, ANA, SMA between essental and secondary HA patients was no significant difference (P>0.05), but there were significantly positive rate with control group (P<0.05), positive rate with URNP, ds-DNA, SSA, Sm, SSB, Jo-1, Scl-70 were undifferentiated among groups. Conclusion: Most HA patients have autobodly mostly are ACA, EMAb, ANA, ASAb, SMA etc.. Caused by the presence of autoantibodies is unexplained habitual abortion causes.
[Key words] Abortion; Habitual; Autoantibodies; Autoimmunity
习惯性流产(habitual abortion，HA)是一种常见的妊娠并发症 ......
您现在查看是摘要介绍页，详见PDF附件(2293kb)。