孟鲁司特治疗支气管哮喘的疗效观察(1)
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[摘要] 目的：探讨孟鲁司特治疗支气管哮喘的临床疗效观察。方法：将96例患者随机分为治疗组和对照组各48例，两组患者均根据病情程度吸入倍氯米松，急性发作期患者应在控制症状后再行治疗，治疗组加用孟鲁司特；对照组常规给予口服特布他林片和酮替酚片。结果：经过治疗，治疗组显效28例，有效19例，无效1例，总有效率为97.9%；对照组显效17例，有效21例，无效10例，总有效率为79.2%；两组总有效率比较，差异有统计学意义(P<0.05)，治疗组疗效明显优于对照组。结论：孟鲁司特在治疗支气管哮喘中能够明显改善患者的肺功能和临床症状，且不良反应少而轻微，疗效显著，是一种安全有效的治疗方法，值得临床推广应用。
[关键词] 孟鲁司特；支气管哮喘；特布他林片；酮替酚片
[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721(2012)01(b)-060-02
Effect observation of bronchial asthma treated with montelukast
LIU Yuchun
The People's Hospital of Jieyang City in Guangdong Province, Jieyang 522000, China
[Abstract] Objective: To explore the effect observation of bronchial asthma treated with montelukast. Methods: Ninty-six patients were divided into treatment group and control group, 48 cases in each. Two groups patients were breathed in beclomethasone according to illness degree, patients in acute-outbreak period were treated after beat sudden attacks, the treatment group added montelukast, the control group treated with terbutaline tablets and ketotifen tablets. Results: After treatment, the treatment group showed effect 28 cases, effected 19 cases, ineffected 1 case, total effective rate was 97.9%; the control group showed effect 17 cases, effected 21 cases, ineffected 10 cases, total effective rate was 79.2%; the total effective rate of the two group had significantly statistical difference (P<0.05), the effective of treatment group was better than control group. Conclusion: Montelukast can improve patients' pulmonary function and clinical symptoms obviously in treatment of bronchial asthma, the untoward effects less and slight, effective in treatment, it is safe and effective method, be worth generalization at clinical.
[Key words] Montelukast; Bronchial asthma; Terbutaline tablets; Ketotifen tablets
支气管哮喘是呼吸系统较为常见的症状之一，是由多种细胞包括肥大细胞、嗜酸粒细胞和T淋巴细胞参与的慢性气道非特异性炎症[1]，其发病率呈逐年上升趋势；在易感者中此种炎症可引起反复发作的喘息、胸闷、咳嗽和气促等症状，常在夜间或凌晨发生，常伴有广泛而多变的可逆性气流受限，病情较重者则产生气道不可逆性狭窄而严重威胁人们的生命健康，因此，对支气管哮喘进行及时、合理、正确的预防和治疗是尤为重要的[2]。近年来，随着医学技术的不断发展，孟鲁司特作为一种新型的抗炎平喘药已被广泛应用于此类疾病的治疗[3]。本院应用孟鲁司特治疗支气管哮喘患者48例，疗效满意，现报道如下：
1 资料与方法
1.1 一般资料
选取本院2009年2月～2010年4月收治的支气管哮喘患者96例，全部患者均符合2008年《支气管哮喘的防治指南》[3]中支气管哮喘诊断标准 ......
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