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胰岛素泵在老年患者2型糖尿病中的临床观察(1)
http://www.100md.com 2012年2月5日 王志慧 杨小洁 樊飞 丁涛
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     [摘要] 目的 通过观察使用CSⅡ(持续性皮下输注)诺和灵R的治疗方式与进行常规性皮下注射诺和灵R与诺和灵N对老年患者2型糖尿病患者的治疗效果进行差异性对比。 方法 选取本院2010年7月~2011年6月收治的2型糖尿病患者共计98例,采用双盲法随机分为两组,A组患者根据血糖指数进行持续皮下输注诺和灵R,而B组分为早、中、晚3次,在每次进餐前30 min根据血糖指数进行皮下注射诺和灵R,在睡前进行皮下注射诺和灵N。通过检测比较两组患者在治疗前与治疗后的血糖、胰岛素用量、血糖指数达标所需时间以及低血糖发生率等各项生理指数。结果 两组患者的空腹血糖值与餐后2 h的血糖值在经过检查后均达到目标值,而与B组相比A组到达指标所需的时间短,日用胰岛素量和总使用量少,低血糖的发病率低,尤其是在夜间A组的低血糖发生率要明显低于B组。结论 与传统治疗方式相比,老年患者2型糖尿病在短期内使用胰岛素泵输注诺和灵R具有明显的降糖作用,不但降低了治疗费用,而且安全性高。

    [关键词] 老年患者;2型糖尿病;胰岛素泵;诺和灵R;诺和灵N

    [中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2012)02(a)-0039-02

    Clinical observation on insulin pump in elderly patients with type 2 diabetes

    WANG Zhihui YANG Xiaojie FAN Fei DING Tao

    Endocrinology Department of Datong Third Hospital in Shanxi Province, Datong 037008, China

    [Abstract] Objective To observe the use of CS Ⅱ (continuous subcutaneous infusion) Novolin R, regular treatment with the subcutaneous injection of Novolin R and Novolin N in elderly patients with type 2 diabetes compared differences in treatment effect. Methods From July 2010 to June 2011 type 2 diabetic patients treated a total of 98 cases in our hospital, double-blind randomized into two groups, group A patients according to glycemic index for the continuous subcutaneous infusion of Novolin R, and group B was divided into early, middle and latethree times, 30 min before each meal according to the glycemic index for subcutaneous Novolin R, subcutaneous injection at bedtime for Novolin N. By comparing the two groups were detected before treatment and after treatment of blood glucose, insulin dose, glycemic index, and the time required to achieve targets incidence of hypoglycemia and other physiological indices. Results Two groups of patients with fasting plasma glucose and 2 h postprandial blood glucose values were checked after the target value, compared with group B and group A, short time required to reach the target, and total daily insulin use less, low incidence of hypoglycemia, especially at night group of the incidence of hypoglycemiawas significantly lower than the occurrence rate of B. Conclusion Compared with conventional treatment, elderly patients with type 2 diabetes in the short term use of insulinpump infusion Novolin R has a significant hypoglycemic effect, not only reduces the cost of treatment, and has high security.

    [Key words] Elderly patients; Type 2 diabetes; Insulin pump; Novolin R; Novolin N ......

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