早期胰岛素治疗对2型糖尿病患者并发症发生率和治疗费用的影响(1)
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[摘要] 目的 观察早期胰岛素治疗对2型糖尿病患者并发症发生率和治疗费用的影响。方法 146例2型糖尿病患者随即分为早期胰岛素治疗组和口服降糖药物组，空腹血糖、餐后2 h血糖、糖化血红蛋白测定评估血糖控制情况；眼底动脉血管检查和尿β2微球蛋白测定法评估并发症的发生率；对比两组因治疗糖尿病及其慢性并发症而花费的医疗费用(包括门诊及住院的医疗费用)。结果 胰岛素组和口服降糖药物组其有并发症或并发症加重的比例分别为25.0和61.8%(χ2=20.99，P < 0.001)；口服降糖药物组总治疗总费用为胰岛素组的3.81倍，而口服降糖药物组并发症治疗费用为胰岛素组的4.20倍。结论 早期胰岛素治疗可以延缓并发症的发生，从而减轻患者的身心痛苦和经济负担。
[关键词] 早期胰岛素治疗；2型糖尿病；并发症；治疗费用
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2012)02(a)-0043-02
Effects of early-phase insulinize on complicating disease and cost in patients with type 2 diabetes
WANG Shufang GUO Yuxiu
Department of Endocrinology, the People's Hospital of Cao County in Shandong Province, Cao County 274400, China
[Abstract] Objective To investigate the effect of early-phase insulinize on complicating diseaseand cost in patients with type 2 diabetes. Methods One hundred and forty six cases of taye 2 diabetes were divided into two groups, early-phase insulinize and oral antidiabetic drug. FPG, 2hPG and HbA1c was used to measure the level of the blood glucose; Fundus examination and urine β2-MG was used to determine the incidence rate of complicating disease; The treatment costs of diabetes and complicating disease were contrasted (the overall expenses of outpatient service and hospitalization). Results The incidence rate of complicating disease in early-phase insulinize group was 25.0%, the contrast group was 61.8%(χ2=20.99, P < 0.001); the total cost of oral antidiabetic drug group was 3.81 times as much as early-phase insulinize group and the cost of complicating disease was 4.2 times. Conclusion Our experiment showed that early-phase insulinize deferred the happening of complicating disease, lightened patients with suffering of body and mind in and economic burden.
[Key words] Early-phase insulinize; Taye 2 diabetes; Complicating disease; Treatment expense
糖尿病已经成为继肿瘤、心血管病之后的第三大严重威胁人类健康的慢性非传染性疾病，是一个日益严重的问题[1]。最新统计资料显示，我国城市治疗2型糖尿病及其并发症的年直接费用为187.5亿元，占卫生费用的3.94%[2]。2型糖尿病是我国乃至全世界的高发病，其慢性并发症更是使2型糖尿病长期处于疾病痛苦的折磨中，其生存质量大大降低。而早期胰岛素治疗可以使胰腺充分休息，改善胰岛素的分泌时相[3]；可以延缓慢性并发症的发生；可以避免长期口服降糖药物所引起的肝肾损害，从而提高患者的生存质量。因此本院2000年7月～2010年7月期间对2型糖尿病患者分别进行早期胰岛素治疗或强化治疗[3]和口服降糖药物两种方法治疗 ......
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